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| | 3,4,5-Trimethoxybenzoyl chloride Basic information |
| Product Name: | 3,4,5-Trimethoxybenzoyl chloride | | Synonyms: | 3,4,5-trimethoxy-benzoylchlorid;Benzoyl chloride, 3,4,5-trimethoxy-;Trimethylgalloyl chloride;Tri-O-methylgalloyl chloride;3,4,5-TRIMETHOXYBENZOYL CHLORIDE;3,4,5-Trimethoxybenzoic acid chloride;AKOS BBS-00003922;sulfuric acid [(8R,9S,13S,14S,16R,17R)-3,16-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] ester | | CAS: | 4521-61-3 | | MF: | C10H11ClO4 | | MW: | 230.64 | | EINECS: | 224-851-4 | | Product Categories: | Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Acid Halides;Carbonyl Compounds;Organic Building Blocks | | Mol File: | 4521-61-3.mol |  |
| | 3,4,5-Trimethoxybenzoyl chloride Chemical Properties |
| Hazard Codes | C | | Risk Statements | 14-34-37 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 1 | | F | 9-21 | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29189900 |
| | 3,4,5-Trimethoxybenzoyl chloride Usage And Synthesis |
| Uses | 3,4,5-Trimethoxybenzoyl Chloride is used as a reagent in the synthesis of 2-methyl-8-(3,4,5-trimethoxybenzamido)-1,2,3,4-tetrahydroisoquinoline and its analogs which display great antihypertensive activity. | | Synthesis | The general procedure for the synthesis of 3,4,5-trimethoxybenzoyl chloride from 3,4,5-trimethoxybenzoic acid was as follows: thionyl chloride (13.7 mL, 189 mmol) was added dropwise to a solution of CHCl3 (30 mL) containing 3,4,5-trimethoxybenzoic acid (8.00 g, 37.7 mmol). After the dropwise addition, the reaction mixture was heated to reflux and maintained for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature. Subsequently, the solvent and excess thionyl chloride were removed by distillation under reduced pressure to afford 3,4,5-trimethoxybenzoyl chloride as a colorless oil in quantitative yield. The obtained product can be used in the subsequent reaction without further purification. The characteristic absorption peaks of the infrared spectrum (NaCl) were: νmax/cm-1 2970, 2944, 1750, 1590, 1457, 1415, 1130, 1128. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 22, p. 5864 - 5869
[2] Tetrahedron, 2011, vol. 67, # 25, p. 4601 - 4611
[3] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 20, p. 6042 - 6054
[4] Letters in Drug Design and Discovery, 2018, vol. 15, # 12, p. 1319 - 1328
[5] Bulletin of the Chemical Society of Japan, 2012, vol. 85, # 2, p. 236 - 244 |
| | 3,4,5-Trimethoxybenzoyl chloride Preparation Products And Raw materials |
| Raw materials | 3,4,5-Trimethoxy benzoic acid-->Chloroform-->Thionyl chloride | | Preparation Products | TROXIPIDE-->Capobenic acid-->3,4,5-Trimethoxyaniline-->3',4',5',5,6,7-HEXAMETHOXYFLAVONE-->Trimethobenzamide-->3,4,5-TRIMETHOXYBENZAMIDE-->1-(3,4,5-Trimethoxybenzoyl)piperidine-->(5-nitroindazol-1-yl)-(3,4,5-trimethoxyphenyl)methanone-->3,4,5-trimethoxy-N-(2-nitrophenyl)benzamide |
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