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BOC Sciences
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Product Name:ZK 93423 hydrochloride
CAS:1216574-52-5
Purity:98% by HPLC Remarks:ZK 93423 hydrochloride is a potent and non-selective benzodiazepine receptor agonist (IC50 = 1 nM) (Ki = 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3γ2, α2β
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| Company Name: |
MedBioPharmaceutical Technology Inc
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021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:ZK 93423 hydrochloride
CAS:1216574-52-5
Purity:98% Package:50mg; 10mg Remarks:Medbio
|
ZK 93423 hydrochloride manufacturers
- ZK 93423 hydrochloride
-
- $1.00 / 1KG
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2019-09-02
- CAS:1216574-52-5
- Min. Order: 1KG
- Purity: ≥98%
- Supply Ability: 200kg
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| | ZK 93423 hydrochloride Basic information |
| | ZK 93423 hydrochloride Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | insoluble in ethanol; <11.71mg/ml in DMSO | | form | solid | | color | Yellow |
| | ZK 93423 hydrochloride Usage And Synthesis |
| Uses | ZK 93423 Hydrochloride, is a potent benzodiazepine receptor agonist (IC50 = 1 nM). | | Biological Activity | zk-93423 is an anxiolytic drug from the β-carboline family, which is a nonbenzodiazepine gabaa receptor agonist. the gabaa receptor is an ligand-gated ion channel and ionotropic receptor. | | in vitro | the full agonist zk-93423 is not subtype selective and stimulates α1, α2, α3, and α5-subunit containing gabaa receptors equally [α1β32 (ki = 4.1 nm), α2β32 (ki = 4.2 nm), α3β32 (ki = 6.0 nm), α5β32 (ki = 4.5 nm), α6β32 (ki >1000 nm)] [1]. zk-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the gabaa receptor. in rats trained to discriminate ptz from saline, the ptz cue was antagonized by zk 93423, which indicated zk 93423 may exhibit anxiolytic quality [2]. | | in vivo | zk 93423 showd to have anxiolytic properties on animal models of anxiety, including social interaction, vogel, geller serfter, 4-plate test and elevated plus-maze. the anxiogenic and anxiolytic actions are mediated by the bdz binding sites [3]. | | IC 50 | 1 nm | | references | [1] cox ed, diaz-arauzo h, huang q, reddy ms, ma c, harris b, mckernan r, skolnick p, cook jm. synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-pbc) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (zk 93423) at wild type and recombinant gabaa receptors. j med chem. 1998 jul 2;41(14):2537-52.
[2] stephens dn, shearman gt, kehr w. discriminative stimulus properties of beta-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors. psychopharmacology (berl). 1984;83(3):233-9.
[3] file se, baldwin ha. effects of beta-carbolines in animal models of anxiety. brain res bull. 1987 sep;19(3):293-9. |
| | ZK 93423 hydrochloride Preparation Products And Raw materials |
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