LSN 3213128
(LSN3213128) manufacturers
- LSN 3213128
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- $2500.00 / 100mg
-
2025-07-28
- CAS:1941211-99-9
- Min. Order:
- Purity:
- Supply Ability: 10g
- LSN 3213128
-
- $2500.00 / 100mg
-
2025-07-21
- CAS:1941211-99-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | LSN 3213128
(LSN3213128) Basic information |
| Product Name: | LSN 3213128
(LSN3213128) | | Synonyms: | LSN 3213128
(LSN3213128);2-Thiophenesulfonamide, N-(6-fluoro-1,2-dihydro-1-oxo-7-isoquinolinyl)-5-[(3R)-3-hydroxy-1-pyrrolidinyl]- | | CAS: | 1941211-99-9 | | MF: | C17H16FN3O4S2 | | MW: | 409.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1941211-99-9.mol |  |
| | LSN 3213128
(LSN3213128) Chemical Properties |
| density | 1.596±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 62.5 mg/mL (152.64 mM) | | form | Solid | | pka | 14.70±0.20(Predicted) | | color | Off-white to pink |
| | LSN 3213128
(LSN3213128) Usage And Synthesis |
| Uses | LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity[1]. | | References | [1] Fales KR, et al. Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransfera DOI:10.1021/acs.jmedchem.7b01046 |
| | LSN 3213128
(LSN3213128) Preparation Products And Raw materials |
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