| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:MT-3014;MT3014,MT 3014
CAS:1332727-40-8
Purity:98% Package:5 mg
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| | 1-[[2-(7-Fluoro-3-methyl-2-quinoxalinyl)-5-[(3R)-3-fluoro- 1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]-2-methyl-2-propanol Monohydrate Basic information |
| | 1-[[2-(7-Fluoro-3-methyl-2-quinoxalinyl)-5-[(3R)-3-fluoro- 1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]-2-methyl-2-propanol Monohydrate Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 14.58±0.29(Predicted) |
| | 1-[[2-(7-Fluoro-3-methyl-2-quinoxalinyl)-5-[(3R)-3-fluoro- 1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]-2-methyl-2-propanol Monohydrate Usage And Synthesis |
| Description | MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively[1].
human PDE 10A|0.062 nM (IC50)|bovine PDE 10A|0.09 nM (IC50)
| | References | [1]. Koizumi Y, et al. Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. Bioorg Med Chem. 2019 Jun 19. |
| | 1-[[2-(7-Fluoro-3-methyl-2-quinoxalinyl)-5-[(3R)-3-fluoro- 1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]-2-methyl-2-propanol Monohydrate Preparation Products And Raw materials |
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