- Bromoacetic acid
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- $0.00 / 1kg
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2024-04-25
- CAS:79-08-3
- Min. Order: 1kg
- Purity: 99
- Supply Ability: 20 tons
- Bromoacetic acid
-
- $0.00 / 1kg
-
2023-10-14
- CAS:79-08-3
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 20tons
- Bromoacetic acid
-
- $0.00 / 1KG
-
2023-09-06
- CAS:79-08-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | Bromoacetic acid Basic information |
| | Bromoacetic acid Chemical Properties |
| Melting point | 46-49 °C | | Boiling point | 208 °C(lit.) | | density | 1 | | vapor pressure | 1 mm Hg @ 550C | | refractive index | 1.4804 (estimate) | | Fp | >110°C | | storage temp. | Store below +30°C. | | solubility | chloroform: soluble10%, clear, colorless | | pka | 2.69(at 25℃) | | form | Crystalline Mass or Crystalline Powder, Flakes, Crystals and/or Chunks | | color | White to yellow | | Water Solubility | miscible | | Sensitive | Light Sensitive & Hygroscopic | | Merck | 14,1400 | | BRN | 506167 | | LogP | -2.3 at 22℃ | | CAS DataBase Reference | 79-08-3(CAS DataBase Reference) | | NIST Chemistry Reference | Acetic acid, bromo-(79-08-3) | | EPA Substance Registry System | Bromoacetic acid (79-08-3) |
| | Bromoacetic acid Usage And Synthesis |
| Chemical Properties | WHITE TO LIGHT YELLOW CRYSTALLINE MASS | | Uses | Bromoacetic acid is used in organic synthesis and as an alkylating agent. It is also used as a biochemical for proteomics research. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, dyes and agrochemicals. | | Uses | Bromoacetic acid is mainly used for the N-terminal bromoacylation of resin bound peptides.
It can also be used:
- To synthesize (Z)-2-(cyclooct-4-en-1-yloxy)acetic acid.
- To synthesize α-bromo-phenylacetamide.
- To convert aromatic thiosemicarbazones to thiazolylhydrazones.
| | Uses | Organic synthesis, abscission of citrus fruit in
harvesting. | | General Description | Aqueous solution. | | Air & Water Reactions | Water soluble. | | Reactivity Profile | Carboxylic acids, such as BROMOACETIC ACID, donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Bromoacetic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. | | Hazard | Strong irritant to skin and tissue. | | Health Hazard | TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | | Fire Hazard | Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. | | Flammability and Explosibility | Non flammable | | Safety Profile | Poison by ingestion,
intraperitoneal, and intravenous routes.
Irritating and corrosive to skin and mucous
membranes. Mutation data reported. When
heated to decomposition it emits toxic
fumes of Br-. See also BROMIDES. | | Purification Methods | Crystallise bromoacetic acid from pet ether (b 40-60o). A diethyl ether solution of it is passed through an alumina column, and the ether is evaporated at room temperature under vacuum. It is best obtained by distillation from a Claisen (flask immersed in an oil bath) fitted with an insulated Vigreux column (p 11) and the fraction b 108-110o/30mm is collected. It is light and moisture sensitive. [Natelson & Gottfried Org Synth Coll Vol III 381 1955, Beilstein 2 IV 526.] LACHRYMATORY and is a skin IRRITANT. |
| | Bromoacetic acid Preparation Products And Raw materials |
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