ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Stem Cells & Wnt >Hedgehog / Smoothened antagonist >CYCLOPAMINE

CYCLOPAMINE

CYCLOPAMINE Suppliers list
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Cyclopamine
CAS:4449-51-8
Purity:HPLC>=98% Package:20mg
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:CYCLOPAMINE
CAS:4449-51-8
Purity:99% Package:1kg;2USD
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: 18080483897
Email: maggie@biopurify.com
Products Intro: Product Name:Cyclopamine
CAS:4449-51-8
Purity:90%~98% HPLC Package:20mg;100mg;500mg;1g Remarks:BP0437
Company Name: Haihang Industry Co.,Ltd
Tel: 86-531-88032799
Email: export@haihangchem.com
Products Intro: Product Name:CYCLOPAMINE
CAS:4449-51-8
Company Name: Chongqing Chemdad Co.,Ltd
Tel: +86-19923101450
Email: sales@chemdad.com
Products Intro: Product Name:cyclopamine
CAS:4449-51-8
Package:1kg,2kg,5kg,10kg,25kg

Lastest Price from CYCLOPAMINE manufacturers

  • Cyclopamine 4449-51-8
  • US $490.00 / g
  • 2020-08-17
  • CAS:4449-51-8
  • Min. Order: 10mg
  • Purity: ≥98%
  • Supply Ability: 1000.00 KGS
  • Cyclopamine
  • US $0.00 / mg
  • 2020-08-14
  • CAS:4449-51-8
  • Min. Order: 20mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 100 g
  • CYCLOPAMINE
  • US $2.00 / kg
  • 2019-07-06
  • CAS:4449-51-8
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
CYCLOPAMINE Basic information
Cyclopamine
Product Name:CYCLOPAMINE
Synonyms:11-DEOXOJERVINE;CyclopaMine, froM VeratruM californiciM;CYCLOPAMINE;Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol,1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetraMethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-;Cyclopamine 11-Deoxojervine (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol;Cyclopamine, >=98%;(3S,6AS,6bS,8aR,10S,12aS,13S,13aS,15aS,15bR)-10,13,14,15b-tetramethyl-1,2,3,4,6,6a,6b,7,7a,8a;11-DEOXYJERVINE
CAS:4449-51-8
MF:C27H41NO2
MW:411.62
EINECS:
Product Categories:Inhibitors;antibiotic;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Lipid signaling
Mol File:4449-51-8.mol
CYCLOPAMINE Structure
CYCLOPAMINE Chemical Properties
Melting point 236-238°C
Boiling point 531.29°C (rough estimate)
density 1.0274 (rough estimate)
refractive index 1.6400 (estimate)
storage temp. 2-8°C
solubility DMSO: soluble
form solid
pka15.05±0.70(Predicted)
Stability:Store in Freezer at - 20°C
Safety Information
Hazard Codes Xi
Safety Statements 22-24/25
WGK Germany 3
RTECS GY0750000
HS Code 29349990
Hazardous Substances Data4449-51-8(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
CYCLOPAMINE Usage And Synthesis
Cyclopaminecyclopamine is a  isosteroidal alkaloid isolated from Veratrum plant , it mainly exists in four kinds of liliaceous plants which include North America Veratrum californicum , Indian Cornlily and Veratrum grandiflorum , Fritillaria pallidiflora Schrenk ,it can be combined with the Smoothened (Smo) protein in Hedgehog signaling pathway , thereby inhibiting the protein activity. It was discovered in the 1960s because of its teratogenic effects , but later nineties studies show that cyclopamine is a hedgehog signaling pathway inhibitor, it has been demonstrated in Drosophila body, since the hedgehog signaling pathway mutations are associated with the pathogenesis of a variety of tumors , recent studies have found that cyclopamine have anti-tumor effects in the adult, which has been confirmed in experiments in vivo or in vitro about pancreatic cancer, bile duct cancer, ovarian cancer, liver cancer and others , but on its researches about gastric cancer cells,it has not been reported in the country . Currently cyclopamine as a potential anti-cancer drug in the world sets off a wave of research.
The above information is edited by the chemicalbook of Tian Ye.
Chemical PropertiesWhite Crystalline Solid
UsesHas antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.1 Solubility: 1mg dissolves in 0.2ml DMSO with heating to approximately 70 degrees (ca. 12 mmol sol.) Solubility: 4mg dissolves in 1ml 95% Ethanol
UsesCyclopamine antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.
Biological ActivityInhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anti-cancer and teratogenic in vivo . Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment.
Anticancer ResearchCyclopamine is a natural compound that inhibits the Hedgehog signaling pathway.Cyclopamine targets Hedgehog by specifically hindering SMO activation.Cyclopamine therapy of murine medulloblastoma resulted in the inhibition ofproliferation, induction of neuronal differentiation, effective depletion of CSCs, andreduction of tumor burden in a mouse tumor allograft. Cyclopamine is effective inkilling of pancreatic, breast, and multiple myeloma CSCs. Cyclopamine incombination with gemcitabine inhibits metastatic spread and reduces primary tumorburden in pancreatic orthotopic xenografts. Mammosphere formation in breastcarcinoma and SC proliferation in multiple myeloma can be reduced by cyclopamine(Kawasaki et al. 2008). The HH ligand activation requires cholesterol at theircarboxyl ends, and 22-OH-cholesterol and 20-OH-cholesterol are reported toincrease the HH target gene expression, and this hypothesis of cholesterol-dependentHH signal transduction is investigated in M2-10B4 pluripotent mesenchymal stemcells. The mechanism underlying the positive regulation of HH signaling by theseoxidative species of cholesterol is not clear. However, this oxidative status ofcholesterol is altered by the endogenous ROS. Hence, the bioactive food componentsthat control the ROS levels can be important in regulating self-renewal and HHpathways (Kim et al. 2012). Cholecalciferol (vitamin D3, an isoform of vitamin D)is reported to be HH antagonist in vitro but not in vivo. Binding of cholecalciferol toSMO receptors results in the reduction of HH signaling in MDAMB231 andC3H/10 T1/2 fibroblast cells. 1 μM vitamin D3 shows more potent SMO inhibitoryaction than 10 μM cyclopamine in PTCH1-transfected C3H/10 T1/2 cells (Kimet al. 2012). Curcumin interferes with the Gli1 mRNA or Gli reporter activity andinhibits HH signaling in transgenic mouse prostate adenocarcinoma cells (Kimet al. 2012).
CYCLOPAMINE Preparation Products And Raw materials
Tag:CYCLOPAMINE(4449-51-8) Related Product Information
Glycitin MONOCROTALINE GANT61 MK-2206 2HCl Vismodegib (GDC-0449) Dasatinib Purmorphamine Ruxolitinib DESPIRO-CYCLOPAMINE BODIPY CYCLOPAMINE N-(2-AMINOETHYL) CYCLOPAMINE Cyclopamine hedgehog 3-HYDROXY-N-AMINOETHYL-N'-AMINOCAPROYLDIHYDROCINNAMOYL CYCLOPAMINE CY-3-CYCLOPAMINE, POTASSIUM SALT,CYANINE-3 CYCLOPAMINE, POTASSIUM SALT FLUORESCEINYL CYCLOPAMINE 3-KETO-N-AMINOETHYL-N'-AMINOCAPROYLDIHYDROCINNAMOYL CYCLOPAMINE CYCLOPAMINE-KAAD,KAAD-CYCLOPAMINE,3-KETO-N-(AMINOETHYL-AMINOCAPROYL-DIHYDROCINNAMOYL)CYCLOPAMINE CYCLOPAMINE