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| | (-)-4-BROMOTETRAMISOLE OXALATE Basic information |
| Product Name: | (-)-4-BROMOTETRAMISOLE OXALATE | | Synonyms: | L-(-)-P-BROMOTETRAMISOLE OXALATE;L-P-BROMOTETRAMISOLE OXALATE;(-)-P-BROMOTETRAMISOLE OXALATE SALT;(-)-P-BROMOLEVAMISOLE OXALATE;R 30402;(S)-(-)-4-BROMOTETRAMISOLE OXALATE;(-)-(S)-6-(4-BROMOPHENYL)-2,3,5,6-TETRAHYDROIMIDAZO[2,1-B]THIAZOLE OXALATE;S(-)-6-(4-BROMOPHENYL)-2,3,5,6-TETRAHYDROIMIDAZO[2,1-B]THIAZOLE OXALATE | | CAS: | 62284-79-1 | | MF: | C13H13BrN2O4S | | MW: | 373.22 | | EINECS: | 263-487-0 | | Product Categories: | Inhibitors;chiral | | Mol File: | 62284-79-1.mol |  |
| | (-)-4-BROMOTETRAMISOLE OXALATE Chemical Properties |
| Melting point | 192 °C (dec.) (lit.) | | Fp | 87℃ | | storage temp. | 2-8°C | | solubility | Soluble in Water (up to 10 mg/ml) | | form | liquid | | color | White | | optical activity | [α]25/D 104°, c = 0.5 in H2O | | BRN | 4944883 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| | (-)-4-BROMOTETRAMISOLE OXALATE Usage And Synthesis |
| Description | Four distinct human isoenzymes of alkaline phosphatase (AP) are known: intestinal (IAP), placental (PLAP), tissue non-specific (NSAP, also known as liver/bone/kidney AP), and germ cell AP (also known as placental-like AP, PLAP-like). L-p-Bromotetramisole is a cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 μM for PLAP and NSAP, respectively). While PLAP is strongly inhibited by L-p-bromotetramisole, a second AP, possibly PLAP-like, shows only partial inhibition. L-p-Bromotetramisole has been shown to inhibit a tyrosine phosphatase from Drosophila and, as a result, is also used as a tyrosine phosphatase inhibitor. | | Chemical Properties | white to light yellow crystal powde | | Uses | L-p-Bromotetramisole Oxalate or (-)-p-Bromotetramisole Oxalate is a potent inhibitor of alkaline phosphatase. | | Biochem/physiol Actions | (-)-p-Bromolevamisole oxalate inhibits L-isoforms of alkaline phosphatases. | | target | alkaline phosphatase | | References | 1) Kovach?et al. (1992),?Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase; J. Natl. Cancer Inst.,?84?515
2) Luo et al. (2000),?Role of protein phosphatases in the activation of CTFR (ABCC7) by genistein and bromotetramisole;?Am. J. Physiol. Cell Physiol.,?279?C108
3) Scher?et al.?(1998),?The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis; Int. J. Oncol.,?12?987 |
| | (-)-4-BROMOTETRAMISOLE OXALATE Preparation Products And Raw materials |
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