| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:SNC 80
CAS:156727-74-1
Package:2.5Mg,50Mg,5Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:SNC 80;(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-diMethyl-1-piperazinyl)-3-Methoxybenzyl]-N,N-diethylbenzaMide
CAS:156727-74-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Product Name: | SNC 80 | | Synonyms: | (+)-4-[(alphaR)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide;4-[(R)-[(2S,5R)-2,5-Dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide;(+)-4-[(Ar)-alpha-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3;NIH 10815;(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAM;(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE;(+)-4-[(AR)-ALPHA-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE;SNC 80 | | CAS: | 156727-74-1 | | MF: | C28H39N3O2 | | MW: | 449.63 | | EINECS: | | | Product Categories: | Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents;Opioid receptor and opioid-like receptor | | Mol File: | 156727-74-1.mol |  |
| | SNC 80 Chemical Properties |
| Melting point | 122-123°C | | Boiling point | 564.8±50.0 °C(Predicted) | | density | 1.040 | | storage temp. | Store at RT | | solubility | DMSO: soluble | | form | solid | | pka | 7.29±0.10(Predicted) | | color | off-white | | Stability: | Store in Freezer | | InChIKey | KQWVAUSXZDRQPZ-UMTXDNHDSA-N | | SMILES | C(N(CC)CC)(=O)C1=CC=C([C@@H](N2C[C@@H](C)N(CC=C)C[C@@H]2C)C2=CC=CC(OC)=C2)C=C1 |
| | SNC 80 Usage And Synthesis |
| Description | SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor. It effectively activates μ/δ receptor heteromers (EC50 = 52.8 nM) but not κ/δ or μ/κ heteromers. SNC 80 has antinociceptive as well as pro-convulsant effects in vivo. | | Chemical Properties | Crystalline Solid | | Uses | Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.5 | | Uses | A highly selective and potent non-peptide -agonist, 2000-fold selective over u-receptors | | Definition | ChEBI: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane. | | Biological Activity | A highly selective and potent non-peptide δ -opioid agonist, 2000-fold selective over μ -opioid receptors. | | Biochem/physiol Actions | SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.2 It also acts as anti-depressant3, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.4 | | storage | Store at RT |
| | SNC 80 Preparation Products And Raw materials |
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