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| | FORTUNELLIN Basic information |
| Product Name: | FORTUNELLIN | | Synonyms: | ACACETIN-7-NEOHESPERIDOSIDE;ACACETIN-7-O-NEOHESPERIDOSIDE;FORTUNELLIN;4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)- | | CAS: | 20633-93-6 | | MF: | C28H32O14 | | MW: | 592.55 | | EINECS: | | | Product Categories: | Tri-substituted Flavones | | Mol File: | 20633-93-6.mol |  |
| | FORTUNELLIN Chemical Properties |
| Melting point | 193-198°C | | Boiling point | 888.7±65.0 °C(Predicted) | | density | 1.62±0.1 g/cm3(Predicted) | | pka | 6.10±0.40(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | FORTUNELLIN Usage And Synthesis |
| Description | Fortunellin is a potential anti-inflammation agent in inflammatory diseases, it targets miR-374a, which is a negative regulator of phosphatase and tensin homolog (PTEN). Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation. | | Chemical Properties | Off-white to light yellow Solid | | Uses | Fortunellin is a flavonoid that can be isolated from kumquat (Fortunella margarita) fruit. Studies have shown that Fortunellin inhibits LPS-induced inflammation and ROS production in H9C2 cells, and also prevents fructose-induced inflammation and oxidative stress by enhancing the AMPK/Nrf2 pathway. In addition, Fortunellin has a dual role in the prevention and treatment of coronaviral disease, with antiviral activity against SARS-CoV-2 and anti-inflammatory immunomodulatory capacity in the host. | | Biological Functions | Fortunellin (acacetin 7-O-neohesperidoside) is a citrus flavonoid isolated from kumquat fruit. Kumquat extract has attracted much attention recently for its beneficial effects on human health, which include antitumor, antioxidant and anti-inflammatory characteristics . The beneficial effects of flavonoids on IBD have been confirmed in many studies. However, although fortunellin is the main flavonoid in kumquat, there is a lack of information on its alleviation of IBD. | | Mechanism of action | Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases. Fortunellin ameliorated colitis symptoms, including excessive inflammation and oxidative stress. Fortunellin decreased epithelial cell apoptosis through inhibiting PTEN expression in colitis. Fortunellin-induced downregulation of PTEN could be counteracted by miR-374a depletion. Moreover, knockdown of miR-374a in vivo partly inhibited the effects of fortunellin on rat colitis. |
| | FORTUNELLIN Preparation Products And Raw materials |
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