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Argatroban

Argatroban Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Argatroban
CAS:74863-84-6
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:74863-84-6
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: Product Name:Argatroban
CAS:74863-84-6
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Argatroban
CAS:74863-84-6
Purity:98% Package:1KG;1USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: linda@hubeijusheng.com
Products Intro: Product Name:Argatroban anhydrous
CAS:74863-84-6
Purity:99% Package:5KG;1KG

Lastest Price from Argatroban manufacturers

  • Argatroban
  • US $6.00 / KG
  • 2020-11-16
  • CAS:74863-84-6
  • Min. Order: 25KG
  • Purity: 99
  • Supply Ability: 999
  • Argatroban
  • US $1.00 / KG
  • 2020-03-06
  • CAS:74863-84-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 200kgs
  • Argatroban
  • US $1.00 / KG
  • 2019-07-06
  • CAS:74863-84-6
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
Argatroban Basic information
Product Name:Argatroban
Synonyms:Argatroban (Mixture of Diastereomers);Argatroban(mixture of isomers);Argatroban;Argipidine;MQP;(2R,4R)-4-Methyl-1-[N-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid;ARG025;MQPA
CAS:74863-84-6
MF:C23H36N6O5S
MW:508.63
EINECS:638-764-8
Product Categories:Amines;Chiral Reagents;Heterocycles;Sulfur & Selenium Compounds;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:74863-84-6.mol
Argatroban Structure
Argatroban Chemical Properties
Melting point 188-1890C
Boiling point 777.2±70.0 °C(Predicted)
density 1.47±0.1 g/cm3(Predicted)
storage temp. Store at +4°C
pka10.44±0.40(Predicted)
form White to off-white powder.
CAS DataBase Reference74863-84-6(CAS DataBase Reference)
Safety Information
MSDS Information
Argatroban Usage And Synthesis
DescriptionArgatroban is a new synthetic antithrombotic agent useful in maintenance anticoagulation them ischemic stroke and disseminated intravascular coagulation. In patients on hemodialysis, argatroban is su enor to heparin, generating a more stable antithrombin effect. Other potential uses include progressing ischemic stroke and disseminated intravascular coagulation.
Chemical PropertiesWhite to Off-White Crystalline Solid
OriginatorMitsubishi Kasei; Daiichi (Japan)
UsesSynthetic thrombin inhibitor. Antithrombotic.
Usesanticoagulant;direct thrombine inhibitor
Brand nameNovastan (Mitsubishi Chemical Corporation, Japan);Slonnon.
PharmacokineticsArgatroban is administered subcutaneously because of the low lipophilicity of the drug. The drug is bound to plasma protein and is metabolized via CYP3A4/5 to the aromatized metabolite and the two hydroxylated metabolites. The M-1 metabolite retains 20 to 30% of the antithrombotic activity. Coadministration of argatroban with inhibitors of CYP3A4 does not appear to produce clinically significant effects. Argatroban is eliminated via biliary secretion into the feces.
Clinical UseArgatroban has been approved for the prophylaxis and treatment of thrombosis in patients with HIT (79). Argatroban is a peptidomimetic that binds selectively to the catalytic site of thrombin as a univalent competitive DTI. Argatroban is available as a mixture of 21-R and 21-S diastereomers (64:36), with the S-isomer approximately twice as potent as the R-isomer. The drug is a reversible inhibitor of both free thrombin as well as clot-bound thrombin.
Tag:Argatroban(74863-84-6) Related Product Information
Argatroban 6-Hydroxy-2(1H)-3,4-dihydroquinolinone Methyl acrylate Basic Violet 1 Haloperidol METSULFURON METHYL Methyl salicylate Tetrahydro Ethoxyquin Diphenoxylate Methanol Methyl Isoquinoline Kresoxim-methyl Quinclorac Methylparaben 5,6,7,8-TETRAHYDROISOQUINOLINE DROPERIDOL