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Thioacetamide

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Company Name: Jinan Chenghui-Shuangda Chemical Co.,Ltd
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Products Intro: Product Name:Thioacetamide
CAS:62-55-5
Purity:99% Package:25KG Remarks:Pharmaceutical intermediate
Company Name: Hebei Yanxi Chemical Co., Ltd.
Tel: +8618633081222
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CAS:62-55-5
Purity:99.9% Package:12.5Kg/Drum;USD
Company Name: Henan DaKen Chemical CO.,LTD.
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Products Intro: Product Name:Thioacetamide
CAS:62-55-5
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: Product Name:62-55-5
CAS:62-55-5
Purity:0.99 Package:25KG,5KG;1KG;500G
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Products Intro: Product Name:Thioacetamide
CAS:62-55-5

Thioacetamide manufacturers

  • Thioacetamide
  • $10.00 / Kg/Drum
  • 2021-12-01
  • CAS:62-55-5
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 10 ton
  • hioacetamide
  • $745.00 / Kg/Bag
  • 2021-11-02
  • CAS:62-55-5
  • Min. Order: 1Kg/Bag
  • Purity: 99
  • Supply Ability: 10T
  • Thioacetamide
  • $873.00 / KG
  • 2021-11-02
  • CAS:62-55-5
  • Min. Order: 25KG
  • Purity: 99%
  • Supply Ability: 200KG
Thioacetamide Basic information
Organic reagents Chemical properties Uses Production method
Product Name:Thioacetamide
Synonyms:Acetamide, thio-;Acetimidic acid, thio-;Acetothioamide;CH3CSNH2;Rcra waste number U218;rcrawastenumberu218;Thiacetamide;THIOACETAMIDE TS
CAS:62-55-5
MF:C2H5NS
MW:75.13
EINECS:200-541-4
Product Categories:API;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Thiocarbonyl Compounds;Sulphur Derivatives
Mol File:62-55-5.mol
Thioacetamide Structure
Thioacetamide Chemical Properties
Melting point 108-112 °C (lit.)
Boiling point 111.7±23.0 °C(Predicted)
density 1.37
refractive index 1.5300 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility passes test2%
form Liquid
pka13.25±0.29(Predicted)
color Off-white to slightly beige
PH Range5.2
PH5.2 (100g/l, H2O, 20℃)
Water Solubility 16.3 g/100 mL (25 ºC)
Merck 14,9319
BRN 506006
Stability:Stability Incompatible with water, mineral acids.
InChIKeyYUKQRDCYNOVPGJ-UHFFFAOYSA-N
CAS DataBase Reference62-55-5(CAS DataBase Reference)
NIST Chemistry ReferenceEthanethioamide(62-55-5)
IARC2B (Vol. 7, Sup 7) 1987
EPA Substance Registry SystemThioacetamide (62-55-5)
Safety Information
Hazard Codes T
Risk Statements 45-22-36/38-52/53
Safety Statements 53-45-61-99
RIDADR 2811
WGK Germany 3
RTECS AC8925000
10
TSCA Yes
HS Code 29309070
Hazardous Substances Data62-55-5(Hazardous Substances Data)
ToxicityMLD orally in rats: 200 mg/kg (Ambrose)
MSDS Information
ProviderLanguage
Ethanethioamide English
SigmaAldrich English
ACROS English
ALFA English
Thioacetamide Usage And Synthesis
Organic reagentsThioacetamide is organic reagent, it is colorless or white crystalline flake. It is dissolved in water, ethanol, very slightly soluble in benzene, ether, the aqueous solution at room temperature or 50~60℃ is fairly stable, when placed 2 to 3 weeks, it is not change, but when hydrogen ions is in the presence, it quickly decomposes into hydrogen sulfide , but hydrolysis increases with alkalinity or acidity of the solution and the temperature rises quickly. Hydrolysis equations solution of thioacetamide in acidic and basic is:
Acidic solution: CH3CSNH2 + 2H2O----(NH4 +) + CH3COO-+ H2S
Alkaline solution: CH3CSNH2 + 2OH-----NH3 + CH3COO-+ HS-
Since H2S or HS-can generate for hydrolysis in acidic or alkaline solution, so in analytical chemistry, it is often used in place of toxic and odor H2S, as the metal cation group reagents or precipitation reagents. The property of resulting precipitate is good, easy to separate. In addition, it can also be used for bismuth measurement reagent. Preparation method: It can be prepared by heating the acetamide with aluminum sulfide, hydrogen sulfide reacting with acetonitrile, or acetamide reacting with K3PS4.
Chemical propertiesIt is colorless or white crystals. Mp is 113-114℃, the solubility in water is 16.3g/100ml at 25℃, ethanol 26.4g/100ml. It is slightly soluble in benzene, ether. Their solution is quite stable at room temperature or 50-60℃, but when hydrogen ions exists, it can generate thiosulfate hydrogen and decompose quickly. New product sometimes has mercaptan odor, slight moisture absorption.
The above information is edited by the chemicalbook of Wang Xiaodong.
Uses1. It can be used for the production of catalysts, stabilizers, polymerization inhibitors, electroplating additives, photographic chemicals, pesticides, dyeing auxiliary and processing agents. It can be also used as polymer curing agents, crosslinking agents, rubber additives and pharmaceutical raw materials.
2. It can be also used as vulcanizing agent and crosslinking agent of polymer, rubber additives, pharmaceutical raw materials, etc.
3. It can be also used as analytical reagents.
Production methodThioacetamide can be obtained by the reaction of acetonitrile with hydrogen sulfide, or acetamide with phosphorus pentasulfide.
DescriptionThioacetamide (TAA) is not known to occur in nature. It is prepared by heating ammonium acetate and aluminum sulfide.
Chemical PropertiesWhite solid
Chemical PropertiesThioacetamide is combustible, crystalline compound. Slight mercaptan odor.
UsesIt is used as an intermediate in organicsynthesis.
UsesSulfide generation
UsesSubstitute for H2S in laboratory qualitative analyses.
DefinitionChEBI: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
General DescriptionWhite crystals with a mercaptan odor.
Air & Water ReactionsSlightly water soluble.
Reactivity ProfileThioacetamide reacts with aqueous acid to generate hydrogen sulfide. Forms addition compounds and sulfides with salts of heavy metals. Hydrolyzed by acids or bases .
HazardToxic by ingestion and inhalation, a possible carcinogen.
Health HazardThe toxicity of this compound is moderatein rats; an oral lethal dose is 200 mg/kg.Oral administration of thioacetamide causedliver cancer in rats and mice. It is, however, a weak liver carcinogen. Malvaldi and associates (1988) investigated the mechanism of its carcinogenic activity on rat liver.Whereas the initiating ability of this compound is quite low, its promoting effect isstrong. Thus thioacetamide is a very effectivepromoter of the liver carcinogenesis. A similar promoting activity of liver carcinogenesishas been observed with other thioamide substances, such as thiobenzamide (Malvaldi et al. 1986).
Low et al. (2004) have proposed a modelto explain thioacetamide-induced hepatotoxicity and cirrhosis in rat livers. The pathways of thioacetamide-induced liver fibrosiswere found to be initiated by thioacetamideS-oxide derived from the biotransformationof thioacetamide by the microsomal flavinadenine nucleotide containing monooxygenase and cytochrome P450 systems andinvolve oxidative stress and depletion ofsuccinyl-CoA, thus affecting heme and ironmetabolism. Karabay et al. (2005) observedsuch hepatic damage in rats with elevationof total nitrite level in livers and decrease inarginase activity. The authors have reportedthat nitrosative stress was essentially the critical factor in thioacetamide-induced hepaticfailure in rats.
Pretreatment of rats with jigrine exhibited hepatoprotective action againstthioacetamide-induced toxicity (Ahmed et al.1999). Thioacetamide decreased the concentration of glutathione in the liver of rats.Jigrine pretreatment, however, restored theglutathione levels to the near normal values.The authors claimed that the effects of jigrinewere comparable to that of silymarin. Thehepatotoxicity in rats was found to potentiatefollowing pretreatment with phenobarbital.
Al-Bader et al. (2000) investigated thetoxicity of thioacetamide in the spleen inexperimental animals. The authors foundan intimate association between the levelsof trace metals and spleen pathology, asobserved in studies of other organs.
Fire HazardFlash point data on Thioacetamide are not available; Thioacetamide is probably combustible.
Safety ProfileConfirmed carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. Exposure has caused liver damage. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also SULFIDES and MERCAPTANS.
Potential ExposureThioacetamide is used as a replacement for hydrogen sulfide in qualitative analyses. Thioacetamide has been used as an organic solvent in the leather, textile, and paper industries; as an accelerator in the vulcanization of buna rubber; and as a stabilizer of motor fuel.
CarcinogenicityThioacetamide is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental FateTAA’s production and use as a substitute for hydrogen sulfide in the laboratory may result in its release to the environment through various waste streams. If released to air, TAA’s estimated vapor pressure indicates that it will exist solely as a vapor in the ambient atmosphere. Vapor-phase TAA will be degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 h. TAA was not biodegraded by activated sludge after 5 days, and therefore may be resistant to biodegradation in the environment. Hydrolysis is not expected since amides hydrolyze very slowly under environmental conditions. An estimated bioconcentration factor for TAA suggests that the potential for bioconcentration in aquatic organisms is low. TAA is expected to be highly mobile in soil, and to volatilize into the atmosphere from moist soil surfaces. In an aquatic environment, most of the substance will leave via volatilization and is not expected to adsorb to solids.
ShippingUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification MethodsCrystallise the amide from absolute diethyl ether or *benzene. Dry it at 70o in a vacuum and store it over P2O5 at 0o under nitrogen. (It develops an obnoxious odour on storage, and absorption at 269nm decreases, hence it should be freshly recrystallised before use). [Beilstein 2 IV 565.]
Toxicity evaluationTAA acts as an indirect hepatotoxin and causes parenchymal cell necrosis. It can be metabolized in vivo to acetamide, which itself is carcinogenic. Acetamide is then hydrolyzed to acetate. TAA-induced liver necrosis has been explained by a scheme that includes the metabolic conversion of TAA to its S-oxide, followed by the further metabolism of TAA-S-oxide to a reactive intermediate that can either bind to liver macromolecules or be further degraded to acetamide and polar products. Examples of TAA’s biochemical effects in the liver include glucose-6- phosphate dehydrogenase being induced within days after rats are treated with TAA, and the level of urea product is decreased as are the activities of hepatic carbamyl phosphate synthetase, ornithine transcarbamylase, and arginase. Thus, TAA can produce marked disturbances in the urea cycle in the liver. Further, TAA administered to rats leads to functional disturbances in mitochondria isolated from livers after 24 h, and the maximum respiratory activity of the mitochondria is also depressed, mitochondrial Ca2+ content is significantly increased, and the Ca2+ transport behavior of the hepatic mitochondria is altered. The results are indicative of structural alterations of the inner mitochondrial membranes. The potential role of TAA in the initiation phase of carcinogenesis may be associated with an increase in nucleoside triphosphate activity in cell nuclear envelopes with a corresponding increase in RNA transport activity. Alterations in the transport phenomenon of nuclear RNA sequences are considered an early response to carcinogens.
IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Treatment in an incinerator, boiler or cement kiln.
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