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Haloperidol

Haloperidol Suppliers list
Company Name: Target Molecule Corp
Tel: 781-999-5354
Email: marketing@targetmol.com
Products Intro: Product Name:Haloperidol;Haldol;Aloperidin;Serenace;Serenace
CAS:52-86-8
Purity:98.83% Package:25 mg;50 mg;100 mg;200 mg;1 mL * 10 mM (in DMSO) Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: Product Name:52-86-8
CAS:52-86-8
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: PI & PI BIOTECH INC.
Tel: 18371201331
Email: Sales@pipitech.com
Products Intro: Product Name:Haloperidol
CAS:52-86-8
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366 E-mail:sales03@shyrchem.com
Email: sales03@shyrchem.com
Products Intro: Product Name:Haloperidol
CAS:52-86-8
Purity:0.98 Package:100g;250g;500g;1kg
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
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Products Intro: Product Name:haloperidol
CAS:52-86-8
Purity:99% Package:5KG;1KG

Lastest Price from Haloperidol manufacturers

  • Haloperidol
  • US $1.00 / KG
  • 2020-01-13
  • CAS:52-86-8
  • Min. Order: 1KG
  • Purity: 98%-99.9%
  • Supply Ability: 100kg
Haloperidol Basic information
Product Name:Haloperidol
Synonyms:Einalon;4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanon;4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone;4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4’-fluoro-butyrophenon;4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4’-fluorobutyrophenone;4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone;4-(4-hydroxy-4’-chloro-4-phenylpiperidino)-4’-fluorbutyrophenone;4-(4-hydroxy-4’-chloro-4-phenylpiperidino)-4’-fluorobutyrophenone
CAS:52-86-8
MF:C21H23ClFNO2
MW:375.86
EINECS:200-155-6
Product Categories:API;HALDOL;Dopamine receptor;Dopamine;Organics;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:52-86-8.mol
Haloperidol Structure
Haloperidol Chemical Properties
Melting point 152 °C
Boiling point 529.0±50.0 °C(Predicted)
density 1.1820 (estimate)
Fp 9℃
storage temp. Store at RT
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL
pka8.3(at 25℃)
form powder
color white
Water Solubility 2.058mg/L(22.5 ºC)
Merck 14,4598
CAS DataBase Reference52-86-8(CAS DataBase Reference)
NIST Chemistry ReferenceHaloperidol(52-86-8)
EPA Substance Registry SystemHaloperidol (52-86-8)
Safety Information
Hazard Codes T,F
Risk Statements 60-61-25-36/37/38-43-39/23/24/25-23/24/25-11
Safety Statements 53-26-36/37/39-45-36/37-16
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS EU1575000
HazardClass 6.1(b)
PackingGroup III
HS Code 2933399090
Hazardous Substances Data52-86-8(Hazardous Substances Data)
ToxicityLD50 orally in rats: 165 mg/kg (Goldenthal); i.p. in mice: 60 mg/kg (Collins, Horlington)
Haloperidol Usage And Synthesis
Chemical PropertiesWhite Crystalline Powder
OriginatorHaldol,Janssen-Le Brun,France,1960
UsesAntidyskinetic; antipsychotic
DefinitionChEBI: A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
Manufacturing ProcessA stirred slurry of 120.0 parts 4-(4-chlorophenyl)-piperidin-4-ol hydrochloride and 40.0 parts of potassium iodide in 500 parts of water is warmed to a temperature of about 35°C under a nitrogen atmosphere. Then, 70.0 parts of potassium hydroxide is added. After further heating to about 55°C. 138.0 parts of 1,1 dimethoxy-1-(4-fluorophenyl)-4-chlorobutane is added. The temperature is then raised to about 102°C and heating continued for 3.5 hours. After cooling to about 75°C. 785 parts of toluene is added to the reaction mixture and stirred for about 5 minutes. An additional 320 parts of toluene is added and the water and organic layers separated. 102 parts of methanol is used to rinse the flask and added to the organic layer to provide a solution of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4,4-dimethoxybutyl]- piperidin-4-ol. Then, 59 parts of concentrated hydrochloric acid is added to a stirred solution of the organic layer to precipitate a solid. The solid is filtered, rinsed twice with 550 parts by volume portions of a 10:9:1 acetone-toluenemethanol mixture, twice with 400 parts by volume portions of a 10:l acetonemethanol mixture, and air-dried. The dried solid is then dissolved in 1,950 parts of methanol with gentle heating on a steam bath. The resulting solution is filtered and 300 parts by volume of concentrated ammonium hydroxide is added. Heating is continued to reflux and maintained thereat for about 1 hour.Then, 2,520 parts of water is added and the slurry stirred at about 75°C for 1.5 hours. After cooling to about 25°C. the solid is filtered, washed twice with 600 parts by volume portions of a 3:1 mixture of water-methanol, and airdried. The resulting product, 4-[4-chlorophenyl)-4-hydroxypiperidino]-4'- fluorobutyrophenone, is obtained in 32.5% yield. This product melts at about 148.5°C to 150.5°C.
Brand nameHaldol (OrthoMcNeil).
Therapeutic FunctionAntidyskinetic, Antipsychotic
General DescriptionHaloperidol, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4-fluorobutyrophenone (Haldol), is anodorless white to yellow crystalline powder. Haloperidol iswell and rapidly absorbed and has a high bioavailability. It ismore than 90% bound to plasma proteins. Haloperidol is excretedslowly in the urine and feces. About 30% of a dose isexcreted in urine and about 20% of a dose in feces via biliaryelimination,and only 1% of a dose is excreted as unchangeddrug in the urine.Haloperidol is a minor substrate of CYP1A2 and a major substrate of CYP2D6 and CYP3A4.CYP2D6 inhibitors may increase the levels/effects ofhaloperidol.Haloperidol may increase the levels/effects ofCYP2D6 substrates and it may decrease the bioactivationof CYP2D6 prodrugs substrates. Haloperidol also is a moderateinhibitor of CYP2D6 and CYP3A4. CYP3A4 inducersmay decrease the levels/effects of haloperidol, whereasCYP3A4 inhibitors may increase the levels/effects ofhaloperidol. Centrally acting acetylcholinesterase inhibitorsmay increase the risk of antipsychotic-related EPS. The precisemechanism of antipsychotic action is unclear but isconsidered to be associated with the potent DA D2receptor–blocking activity in the mesolimbic system and theresulting adaptive changes in the brain. Haloperidol is usedprimarily for the long-term treatment of psychosis and is especiallyuseful in patients who are noncompliant with theirdrug treatment.
General DescriptionHaloperidol, 4[4-(p-chlorophenyl)-4-hydroxypiperidone]-4' -n-fluorobutyrophenone (Haldol),the representative of several related classes of aromaticbutylpiperidine derivatives, is a potent antipsychotic usefulin schizophrenia and in psychoses associated with braindamage. It is frequently chosen as the agent to terminatemania and often used in therapy for Gilles de la Tourettesyndrome. Haloperidol-induced dyskinesias may involveneurotoxicological metabolite similar to dopaminergic toxicantMPP+.
Pharmaceutical ApplicationsHaloperidol is an analogue of the dopamine D2 receptor antagonist and is an older antipsychotic drug. The drug is used in the treatment of schizophrenia, a neuropsychiatric disorder. In general, antipsychotic drugs work by blocking the dopamine D2 receptors.
Haloperidol is such an antipsychotic drug, which was developed in the 1950s and entered the clinic soon after that. Its use is limited by the high incidence of extrapyramidal symptoms (movement disorders caused by drugs affecting the extrapyramidal system, a neural network which is part of the motor system). Nevertheless, haloperidol may be used for the rapid control of hyperactive psychotic states and is popular for treating restlessness in the elderly.
Biological ActivityDopamine antagonist with selectivity for D 2 -like receptors (K i values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively). Subtype-selective NMDA antagonist.
Tag:Haloperidol(52-86-8) Related Product Information
HALOPERIDOL RELATED COMPOUND A 4,4-BIS[4-P-CHLOROPHENYL)-4-HYDROXY-PIPERIDINO]BUTYROPHENONE USP(CRM STANDARD) IOHEXOL IMPURITY J HALOPERIDOL ASSAY STANDARD BP(CRM STANDARD) IOHEXOL IMPURITY A haloperidol hemisuccinate HALOPERIDOL, TG CONJUGATE clofluperol HALOPERIDOL-D4,100/MLINMETHANOL,HALOPERIDOL-D4 HALOPERIDOL HYDROCHLORIDE HALOPERIDOL, [3H(G)]- TriphenylMethyl chloride Haloperidol caprate Chlorodimethylphenylsilane Diphenoxylate 2-Butanone tert-Butylchlorodiphenylsilane CHLOROPHOSPHONAZO III Haloperidol