|
|
| | AG 490 Chemical Properties |
| Melting point | 215 | | Boiling point | 615.2±55.0 °C(Predicted) | | density | 1.337±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | ethanol: 5 mg/mL | | pka | 8.82±0.35(Predicted) | | form | solid | | color | yellow | | CAS DataBase Reference | 134036-52-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-50-25 | | Safety Statements | 26-36-61-45 | | WGK Germany | 1 | | Hazard Note | Irritant/Keep Cold under -20C | | HS Code | 2926907090 |
| | AG 490 Usage And Synthesis |
| Chemical Properties | Pale Yellow-Green Crystal | | Uses | A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo. | | Uses | Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. | | Definition | ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide. |
| | AG 490 Preparation Products And Raw materials |
|