| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
|
| Tel: |
020-39119399 18927568969 |
| Email: |
isunpharm@qq.com |
| Products Intro: |
Product Name:Zaragozic acid A trisodium salt
CAS:144541-82-2
Purity:95% (HPLC) Package:5MG; 25MG; 100MG; 1G
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Zaragozic acid A
CAS:144541-82-2
Purity:>=95% (HPLC) Package:5mg Remarks:Z2626
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:ZaragozicAcidATrisodiumSalt
CAS:144541-82-2
Purity:NULL Package:1mg;2.5mg;5mg Remarks:NULL
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| Company Name: |
Shanghai Universal Biotech Co.,Ltd
|
| Tel: |
18768175414 |
| Email: |
gaojun@univ-bio.com |
| Products Intro: |
Product Name:Zaragozic acid A trisodium salt
Package:5mg Remarks: 见优宁维官网
|
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| | SQUALESTATIN Basic information |
| Product Name: | SQUALESTATIN | | Synonyms: | SQUALESTATIN;L-694,599;ZARAGOZIC ACID A SODIUM SALT;Zaragozic acid A trisodium salt | | CAS: | 144541-82-2 | | MF: | C35H47NaO14 | | MW: | 714.74 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | SQUALESTATIN Chemical Properties |
| | SQUALESTATIN Usage And Synthesis |
| Uses | Zaragozic acid A trisodium salt is a potent inhibitor of squalene synthase. | | Uses | Zaragozic acid A trisodium salt has been used as:
- a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
- a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
- a cholesterol synthesis inhibitor in T cells
| | Biochem/physiol Actions | Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels. |
| | SQUALESTATIN Preparation Products And Raw materials |
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