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| ESCHENMOSER'S SALT Basic information |
Product Name: | ESCHENMOSER'S SALT | Synonyms: | ESCHENMOSER SALT;ESCHENMOSER'S SALT;N,N-DIMETHYLMETHYLENEAMMONIUM CHLORIDE;N,N-DIMETHYL-METHYLENEIMINIUM CHLORIDE;N,N-dimethylmethyleneammonium bromide;dimethylmethylenammonium chloride;N,N-DIMETHYLMETHYLENEAMMONIUM CHLORIDE, TECH., 90%;Methanaminium, N-methyl-N-methylene-, chloride | CAS: | 30354-18-8 | MF: | C3H8ClN | MW: | 93.56 | EINECS: | 250-142-4 | Product Categories: | | Mol File: | 30354-18-8.mol | |
| ESCHENMOSER'S SALT Chemical Properties |
Melting point | 146-148 °C(lit.) | Fp | 180 °F | storage temp. | Store below +30°C. | solubility | Chloroform (Very Slightly, Heated), DMSO (Sparingly, Heated, Sonicated) | form | Solid | color | White to Off-White | BRN | 505955 | Stability: | Hygroscopic, Unstable in Protic Solvent |
| ESCHENMOSER'S SALT Usage And Synthesis |
Uses | N,N-Dimethylmethyleneiminium chloride (B?hme′s salt) is a dimethylaminomethylating agent that can be used as one of the key reagents in the following applications:
- Electrophilic aminomethylation of aldehydes and ketones to synthesize corresponding Mannich products, also known as Mannich reaction.
- Preparation of dihydronaphthyridinones as HIV-1 integrase inhibitors.
- Preparation of cyanotetrahydrooxo-β-carbolines via cyclocondensation of cyanomethyl indole-2-carboxylate with ammonia.
- Asymmetric synthesis of phalarine via stereospecific Pictet-Spengler cyclocondensation and traceless chirality transfer from L-tryptophan.
- Synthesis of functionalized diarylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX).
- Synthesis of (±)-phalarine with the rearrangement of an azaspiroindolenine and Gassman oxindole preparation as key steps.
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| ESCHENMOSER'S SALT Preparation Products And Raw materials |
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