| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:ADRA1D receptor agonist 1
CAS:1191908-14-1
Remarks:Reach out to us for more information about custom solutions.
|
ADRA1D receptor agonist 1 manufacturers
|
| | ADRA1D receptor agonist 1 Basic information |
| Product Name: | ADRA1D receptor agonist 1 | | Synonyms: | ADRA1D receptor agonist 1;ADRA1D receptor antagonist 1;ADRA-1D receptor antagonist 1,ADRA1D receptor antagonist 1;ADRA1D receptor antagonist 1 HCl | | CAS: | 1191908-14-1 | | MF: | C15H14Cl2N4O | | MW: | 337.2 | | EINECS: | | | Product Categories: | | | Mol File: | 1191908-14-1.mol |  |
| | ADRA1D receptor agonist 1 Chemical Properties |
| form | Solid | | color | Yellow to brown |
| | ADRA1D receptor agonist 1 Usage And Synthesis |
| Uses | ADRA1D receptor antagonist 1 is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM[1]. | | in vivo | ADRA1D receptor antagonist 1 (4.4 μg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO[1].
| Animal Model: | Rat with bladder outlet obstruction (BOO)[1] | | Dosage: | 4.4 μg/kg | | Administration: | Intravenous injection | | Result: | Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO. |
| | References | [1] Sakauchi N, et al. Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ethe DOI:10.1021/acs.jmedchem.5b01528 |
| | ADRA1D receptor agonist 1 Preparation Products And Raw materials |
|