化合物SYNUCLEAN-D
中文名称 | 化合物SYNUCLEAN-D |
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中文同义词 | 化合物SYNUCLEAN-D |
英文名称 | SC-D |
英文同义词 | SynuClean-D;SynuClean-D,inhibit,Inhibitor,SynuClean D,SynuCleanD;3-Pyridinecarbonitrile, 1,2-dihydro-5-nitro-6-(3-nitrophenyl)-2-oxo-4-(trifluoromethyl)- |
CAS号 | 685121-45-3 |
分子式 | C13H5F3N4O5 |
分子量 | 354.2 |
EINECS号 | |
相关类别 | |
Mol文件 | 685121-45-3.mol |
结构式 |
化合物SYNUCLEAN-D 性质
沸点 | 416.6±45.0 °C(Predicted) |
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密度 | 1.68±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:83.33 mg/mL(235.26 mM) |
酸度系数(pKa) | 1.72±0.10(Predicted) |
SynuClean-D significantly reduces the in vitro aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. Computational analysis suggests that SynuClean-D can bind to cavities in mature α-synuclein fibrils and, indeed, it displays a strong fibril disaggregation activity.
The treatment with SynuClean-D of two parkinson’s disease (PD) Caenorhabditis elegans models, expressing α-synuclein either in muscle or in dopaminergic neurons, significantly reduces the toxicity exerted by α-synuclein. SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. More importantly, this compound is able to rescue dopaminergic neurons from α-synuclein-induced degeneration.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-124876 | 化合物SYNUCLEAN-D SynuClean-D | 685121-45-3 | 5mg | 4500元 |
2024/04/30 | HY-124876 | 化合物SYNUCLEAN-D SynuClean-D | 685121-45-3 | 10mM * 1mLin DMSO | 4950元 |