| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:SynuClean-D
CAS:685121-45-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
|
| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:SynuClean-D
CAS:685121-45-3
Purity:98% Package:5mg;10mg;50mg;100mg
|
SC-D manufacturers
- SynuClean-D
-
- $139.00 / 1mg
-
2025-11-10
- CAS:685121-45-3
- Min. Order:
- Purity: 99.25%
- Supply Ability: 10g
- SynuClean-D
-
- $139.00 / 1mg
-
2025-11-10
- CAS:685121-45-3
- Min. Order:
- Purity: 99.25%
- Supply Ability: 10g
|
| Product Name: | SC-D | | Synonyms: | SynuClean-D;SynuClean-D,inhibit,Inhibitor,SynuClean D,SynuCleanD;3-Pyridinecarbonitrile, 1,2-dihydro-5-nitro-6-(3-nitrophenyl)-2-oxo-4-(trifluoromethyl)-;SynuClean-D, 10 mM in DMSO | | CAS: | 685121-45-3 | | MF: | C13H5F3N4O5 | | MW: | 354.2 | | EINECS: | | | Product Categories: | | | Mol File: | 685121-45-3.mol |  |
| Boiling point | 416.6±45.0 °C(Predicted) | | density | 1.68±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 83.33 mg/mL (235.26 mM) | | form | Solid | | pka | 1.72±0.10(Predicted) | | color | White to yellow |
| Uses | SynuClean-D (SC-D) is an inhibitor of α-synuclein aggregation, disrupts mature amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease[1]. | | in vivo | The treatment with SynuClean-D of two parkinson’s disease (PD) Caenorhabditis elegans models, expressing α-synuclein either in muscle or in dopaminergic neurons, significantly reduces the toxicity exerted by α-synuclein. SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. More importantly, this compound is able to rescue dopaminergic neurons from α-synuclein-induced degeneration[1]. | | IC 50 | α-synuclein Aggregation | | References | [1] Pujols J, et al. Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10481-10486. DOI:10.1073/pnas.1804198115 |
| | SC-D Preparation Products And Raw materials |
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