| Company Name: |
Affinity（Wuhan）Ltd.
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| Tel: |
15841022315 |
| Email: |
sales@affinitytech.cn |
| Products Intro: |
Product Name:BCN-PEG4-HyNic
CAS:1507370-54-8
Purity:>96% Package:100mg;1g;10g
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| Company Name: |
Henan Mengtai Pharmaceutical Technology Co., Ltd
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| Tel: |
176345344 7 17634854698 |
| Email: |
1959525201@qq.com |
| Products Intro: |
Product Name:5,8-Dioxa-2,11-diazadodecanoic acid, 12-[6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinyl]-12-oxo-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester
CAS:1507370-54-8
Purity:98% HPLC
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| Company Name: |
YantaiBio
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| Tel: |
13758194781 15083780366 |
| Email: |
wudegui@tanzhenbio.com |
| Products Intro: |
Product Name:BCN-PEG4-HyNic
CAS:1507370-54-8
Purity:98% HPLC Package:5mg; 100mg; 1g
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| | 5,8-Dioxa-2,11-diazadodecanoic acid, 12-[6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinyl]-12-oxo-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester Basic information |
| Product Name: | 5,8-Dioxa-2,11-diazadodecanoic acid, 12-[6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinyl]-12-oxo-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | | Synonyms: | 5,8-Dioxa-2,11-diazadodecanoic acid, 12-[6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinyl]-12-oxo-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester;BCN-PEG4-HyNic;5,8-Dioxa-2,11-diazadodecanoic acid, 12-[6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinyl]-12-oxo-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | | CAS: | 1507370-54-8 | | MF: | C26H37N5O5 | | MW: | 499.61 | | EINECS: | | | Product Categories: | ADC LINKER | | Mol File: | 1507370-54-8.mol | ![5,8-Dioxa-2,11-diazadodecanoic acid, 12-[6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinyl]-12-oxo-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester Structure](CAS/20211123/GIF/1507370-54-8.gif) |
| | 5,8-Dioxa-2,11-diazadodecanoic acid, 12-[6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinyl]-12-oxo-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester Chemical Properties |
| density | 1.24±0.1 g/cm3(Predicted) | | pka | 12.05±0.46(Predicted) |
| | 5,8-Dioxa-2,11-diazadodecanoic acid, 12-[6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinyl]-12-oxo-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester Usage And Synthesis |
| Uses | BCN-PEG4-HyNic is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. BCN-PEG4-HyNic is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | Acid Cleavable Linker; Cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | 5,8-Dioxa-2,11-diazadodecanoic acid, 12-[6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinyl]-12-oxo-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester Preparation Products And Raw materials |
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