| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-164-7117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:(2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS:2502156-03-6
Purity:98% Package:1mg;5mg;10mg;25mg;50mg; Remarks:BD01255712
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| | PROTAC KRASG12C Degrader-LC-2 Basic information |
| Product Name: | PROTAC KRASG12C Degrader-LC-2 | | Synonyms: | PROTAC KRASG12C Degrader-LC-2;LC-2;(2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-m;L-Prolinamide, N-[3-[3-[(2S)-2-[[[7-(8-chloro-1-naphthalenyl)-4-[(3S)-3-(cyanomethyl)-4-(2-fluoro-1-oxo-2-propen-1-yl)-1-piperazinyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl]oxy]methyl]-1-pyrrolidinyl]propoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | | CAS: | 2502156-03-6 | | MF: | C59H71ClFN11O7S | | MW: | 1132.78 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![PROTAC KRASG12C Degrader-LC-2 Structure]() |
| | PROTAC KRASG12C Degrader-LC-2 Chemical Properties |
| density | 1.297±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 50 mg/mL (44.14 mM; ultrasonic and warming and heat to 80°C) | | form | Solid | | pka | 14.07±0.40(Predicted) | | color | Off-white to brown |
| | PROTAC KRASG12C Degrader-LC-2 Usage And Synthesis |
| Description | LC-2 is a von Hippel-Lindau-based PROTAC which can degrade endogenous KRAS G12C. It covalently binds KRAS G12C with a MARTX849 warhead and recruits the E3 ligase VHL which degrades the KRAS G12C and suppresses MAPK signaling in homozygous and heterzygous KRAS G12C cell lines. | | storage | Store at -20°C |
| | PROTAC KRASG12C Degrader-LC-2 Preparation Products And Raw materials |
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