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| Product Name: | SC-514 | | Synonyms: | SC-514, >=98%;3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide;SC-514;GK 01140;IKK-2 Inhibitor, SC-514;4-Amino-[2',3'-bithiophene]-5-carboxamide;SC-514;5-(Thien-3-yl)-3-aminothiophene-2-carboxamide;GK 01140 | | CAS: | 354812-17-2 | | MF: | C9H8N2OS2 | | MW: | 224.3 | | EINECS: | | | Product Categories: | NF-kB;IκB/IKK;Apis;All Inhibitors;Inhibitors | | Mol File: | 354812-17-2.mol |  |
| | SC-514 Chemical Properties |
| Melting point | 209-211°C | | Boiling point | 399.2±42.0 °C(Predicted) | | density | 1.450±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | pka | 15.63±0.50(Predicted) | | form | powder | | color | white to light brown | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | WGK Germany | 3 |
| | SC-514 Usage And Synthesis |
| Description | SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the transcription of NF-κB dependent genes in cell culture.1 | | Chemical Properties | Yellow Solid | | Uses | A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, | | Uses | A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF. | | Definition | ChEBI: 3-amino-5-(3-thiophenyl)-2-thiophenecarboxamide is a ring assembly and a member of thiophenes. | | storage | Store at +4°C | | References | 1) Kishore et al. (2003), A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts; J. Biol. Chem., 278 32861 |
| | SC-514 Preparation Products And Raw materials |
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