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Docetaxel

Docetaxel Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:Docetaxel,125354-16-7
CAS:125354-16-7
Purity:99% Package:25KG;5KG;1KG
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070
Email: product@chemlin.com.cn
Products Intro: CAS:125354-16-7
Purity:98% Package:g-Kg Remarks:White or almost white crystalline powder
Company Name: Nanjing Finetech Chemical Co., Ltd.
Tel: 025-85710122 17714198479
Email: sales@fine-chemtech.com
Products Intro: CAS:125354-16-7
Purity:99%min Package:1KG;10KG;100KG;500KG;100g Remarks:ISO certified
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Docetaxel
CAS:125354-16-7
Purity:98% Package:1KG;1USD
Company Name: Shenzhen Nexconn Pharmatechs Ltd
Tel: +86-755-89396905 +86-15013857715
Email: admin@nexconn.com
Products Intro: Product Name:Docetaxel
CAS:125354-16-7
Purity:0.98 Package:1KG;10KG;50KG

Docetaxel manufacturers

  • Docetaxel
  • Docetaxel pictures
  • $0.00 / 1KG
  • 2024-03-16
  • CAS:125354-16-7
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • Docetaxel USP/EP/BP
  • Docetaxel USP/EP/BP pictures
  • $1.10 / 1g
  • 2021-07-03
  • CAS:125354-16-7
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons Min
  • Docetaxel
  • Docetaxel pictures
  • $0.00 / 1Kg
  • 2020-05-03
  • CAS:125354-16-7
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 800 ton

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  • Aug 20,2019
Docetaxel Basic information
Product Name:Docetaxel
Synonyms:10-Acetyldocetaxel;10-Acetyltaxotere;Docetaxal;PNU 101383;ACETYLDOCETAXEL, 10-(P);Docetaxel N-Debenzoyl-N-(tert-butoxycarbonyl)taxol;DOCETAXOL;N-Debenzoyl-N-(tert-butoxycarbonyl)taxol
CAS:125354-16-7
MF:C45H55NO15
MW:849.93
EINECS:1533716-785-6
Product Categories:
Mol File:125354-16-7.mol
Docetaxel Structure
Docetaxel Chemical Properties
Melting point 201-203 °C(Solv: methanol (67-56-1))
Boiling point 901.4±65.0 °C(Predicted)
density 1.36±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka11.20±0.46(Predicted)
color White to Off-White
Safety Information
MSDS Information
Docetaxel Usage And Synthesis
UsesDocetaxal (Docetaxel EP Impurity G) is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.
UsesDocetaxal is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de -polymerization to free tubulin.
General DescriptionDocetaxel is available in single-dose vials of 20 mg/0.5 mLand 80 mg/2 mL for IV administration in the treatment of breast, NSCLC, and prostate cancers. It has also been utilizedin non–FDA-approved treatment of head, neck, gastric,bladder, and refractory ovarian cancers.
Docetaxel is highly plasma protein bound (80%) andwidely distributed with the highest concentration in the hepatobiliarysystem, but it does not appear to cross the bloodbrainbarrier. The metabolism of docetaxel has been lesswell studied than that of paclitaxel. The use of human livermicrosomes has indicated that metabolism involves oxidationof one of the tert-butyl methyl groups of the C-13 sidechain to initially give the alcohol. Further oxidation to thealdehyde and carboxylic acid both of which may cyclizewith the carbamate nitrogen to give stereoisomeric hydroxyoxazolidinonesand an oxazolidinedione, respectively. Noactive metabolites have been identified. The major enzymeinvolved is CYP3A4. The drug is primarily eliminated in thefeces with a terminal half-life of 11 hours.
The adverse effects profile for docetaxel is similar to thatof paclitaxel but also includes reversible fluid retention that isdose related. This has been associated with an initial increasein capillary permeability followed by a decrease in lymphaticdrainage later in the therapy. Restriction of sodium intake andpretreatment with corticosteroids is usually successful inminimizing this adverse effect. Peripheral neuropathy is seenwith docetaxel but occurs less often than with paclitaxel.Fatigue and muscle pain are commonly seen, and fever mayoccur in up to 30% of patients who are infection free.
Docetaxel Preparation Products And Raw materials
Tag:Docetaxel(125354-16-7) Related Product Information
Docetaxel Paclitaxel tert-Butanol tert-Butyl peroxyacetate tert-Butyl acetate DOCETAXEL HYDRATE,Docetaxel trihydrate (2R,3S)-2-HYDROXY-3-(N-TERTBUTOXYCARBONYL) AMINO-3- PHENYL- METHYL PROPIONATE (INTERMEDIATE OF DOCETAXEL) SIDE CHAINS OF DOCETAXEL--4 SIDE CHAINS OF DOCETAXEL--1 SIDE CHAINS OF DOCETAXEL--3 10-Oxo Docetaxel 13-O-(Triethylsilyl) Baccatin III 2-Debenzoyl-2-pentenoyl Docetaxel Docetaxel Impurity 5 Docetaxel impurity 1/(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-6,9,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((2,2,2-trichloroethoxy)carbonyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Docetaxel Impurity 36 (2S,3S)-methyl 3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropanoate Docetaxel Impurity 15