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Diethyl chlorothiophosphate

Diethyl chlorothiophosphate Basic information
Product Name:Diethyl chlorothiophosphate
Synonyms:Diethoxythiophosphoryl chloride;diethoxythiophosphorylchloride;Diethyl phosphorochloridothioate;Diethyl phosphorothiochloridate;Diethyl phosphorothionochloridate;Diethyl thiophosphoric chloride;Diethylchlorthiofosfat;diethylchlorthiofosfat(czech)
Product Categories:Pharmaceutical Intermediates;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Phosphorylating and Phosphorothioating Agents;Protecting Agents, Phosphorylating Agents & Condensing Agents;Miscellaneous Reagents, Sulfur & Selenium Compounds
Mol File:2524-04-1.mol
Diethyl chlorothiophosphate Structure
Diethyl chlorothiophosphate Chemical Properties
Melting point -75℃
Boiling point 96 °C
density 1.2 g/mL at 25 °C(lit.)
vapor pressure 1.4 mm Hg ( 50 °C)
refractive index n20/D 1.472(lit.)
Fp >230 °F
form liquid
Water Solubility hydrolyzes, immiscible
CAS DataBase Reference2524-04-1(CAS DataBase Reference)
NIST Chemistry ReferencePhosphorochloridothioic acid, o,o'-diethyl ester(2524-04-1)
EPA Substance Registry SystemPhosphorochloridothioic acid, O,O-diethyl ester(2524-04-1)
Safety Information
Hazard Codes T,T+
Risk Statements 23/24/25-34-26-21/22
Safety Statements 23-26-36/37/39-45-28A
RIDADR UN 2751 8/PG 2
WGK Germany 3
RTECS TD1780000
HazardClass 8
PackingGroup II
Hazardous Substances Data2524-04-1(Hazardous Substances Data)
MSDS Information
Diethyl chlorothiophosphate English
SigmaAldrich English
Diethyl chlorothiophosphate Usage And Synthesis
UsesDiethyl Chlorothiophosphate is used in the preparation of various organophosporus insecticide including Flupyrazofos (F598620) and Chlorpyrifos (C425300).
General DescriptionA colorless to light amber liquid with a disagreeable odor. Density 1.196 g / cm3. Boiling point 120°F.Flash point below 100°F. Insoluble in water but soluble in most organic solvents. May be highly toxic and irritating to the eyes and lungs. Used as an intermediate for pesticides, as an oil and gasoline additive, and as a flame retardant.
Air & Water ReactionsHighly flammable. Insoluble in water but soluble in most organic solvents. Contact with moisture in the air produces highly corrosive and toxic fumes containing hydrogen chloride. Decomposes in water producing acidic products.
Reactivity ProfileDiethyl chlorothiophosphate is incompatible with bases (including amines), with strong oxidizing agents, and with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health HazardTOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire HazardHIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Tag:Diethyl chlorothiophosphate(2524-04-1) Related Product Information
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