| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:5-HT2CR agonist 1
CAS:1216074-15-5
Package:50mg/RMB 13800
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| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Email: |
info@biorbyt.com |
| Products Intro: |
Product Name:5-HT2CR agonist 1
CAS:1216074-15-5
|
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| | Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- Basic information |
| | Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- Chemical Properties |
| Boiling point | 367.9±42.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | pka | 9.59±0.20(Predicted) |
| | Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- Usage And Synthesis |
| Uses | 5-HT2CR agonist 1 (compound 8), a 7-chloro analogue, is a selective 5-HT2CR partial agonist (Emax=71.09%) with an EC50 value of 121.5 nM and no observed activity toward 5-HT2AR or 5-HT2BR. 5-HT2CR agonist 1 exhibits no recruitment activity for β-arrestin and shows low inhibition of hERG at 10 μM[1]. | | IC 50 | 5-HT2C Receptor: 121.5 nM (EC50) | | References | [1] Guangqian Jiang, et al Identification of Spiro[chromene-2,4′-piperidine]s as Potent, Selective, and Gq-Biased 5-HT2C Receptor Partial Agonists. ACS Med. Chem. Lett. December 18, 2023. |
| | Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- Preparation Products And Raw materials |
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