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L-Threoninamide, N2,N6-bis[2-[[[(8β)-6-propylergolin-8-yl]methyl]thio]acetyl]-D-lysyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-(2S)-2-aminobutanoyl-L-cysteinyl-, cyclic (2→7)-disulfide

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L-Threoninamide, N2,N6-bis[2-[[[(8β)-6-propylergolin-8-yl]methyl]thio]acetyl]-D-lysyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-(2S)-2-aminobutanoyl-L-cysteinyl-, cyclic (2→7)-disulfide Basic information
Product Name:L-Threoninamide, N2,N6-bis[2-[[[(8β)-6-propylergolin-8-yl]methyl]thio]acetyl]-D-lysyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-(2S)-2-aminobutanoyl-L-cysteinyl-, cyclic (2→7)-disulfide
Synonyms:L-Threoninamide, N2,N6-bis[2-[[[(8β)-6-propylergolin-8-yl]methyl]thio]acetyl]-D-lysyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-(2S)-2-aminobutanoyl-L-cysteinyl-, cyclic (2→7)-disulfide;TBR-760;BIM-23A760;Onzigolide
CAS:778630-77-6
MF:C86H116N16O12S4
MW:1694.21
EINECS:
Product Categories:
Mol File:778630-77-6.mol
L-Threoninamide, N2,N6-bis[2-[[[(8β)-6-propylergolin-8-yl]methyl]thio]acetyl]-D-lysyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-(2S)-2-aminobutanoyl-L-cysteinyl-, cyclic (2→7)-disulfide Structure
L-Threoninamide, N2,N6-bis[2-[[[(8β)-6-propylergolin-8-yl]methyl]thio]acetyl]-D-lysyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-(2S)-2-aminobutanoyl-L-cysteinyl-, cyclic (2→7)-disulfide Chemical Properties
density 1.39±0.1 g/cm3(Predicted)
pka9.90±0.15(Predicted)
Safety Information
MSDS Information
L-Threoninamide, N2,N6-bis[2-[[[(8β)-6-propylergolin-8-yl]methyl]thio]acetyl]-D-lysyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-(2S)-2-aminobutanoyl-L-cysteinyl-, cyclic (2→7)-disulfide Usage And Synthesis
UsesOnzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors[1][2].
IC 50SSTR2
References[1] Halem HA, et al. TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice. Endocrinology. 2020 Aug 1;161(8):bqaa101. DOI:10.1210/endocr/bqaa101
[2] Cuny T, et al. Characterization of the ability of a, second-generation SST-DA chimeric molecule, TBR-065, to suppress GH secretion from human GH-secreting adenoma cells. Pituitary. 2021 Jun;24(3):351-358. DOI:10.1007/s11102-020-01113-4
L-Threoninamide, N2,N6-bis[2-[[[(8β)-6-propylergolin-8-yl]methyl]thio]acetyl]-D-lysyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-(2S)-2-aminobutanoyl-L-cysteinyl-, cyclic (2→7)-disulfide Preparation Products And Raw materials
Tag:L-Threoninamide, N2,N6-bis[2-[[[(8β)-6-propylergolin-8-yl]methyl]thio]acetyl]-D-lysyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-(2S)-2-aminobutanoyl-L-cysteinyl-, cyclic (2→7)-disulfide(778630-77-6) Related Product Information
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