| Company Name: |
Shanghai SuperLan Chemcial Technique Centre
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| Tel: |
021-2022843681 15618226720 |
| Email: |
lucy@atkchemical.com |
| Products Intro: |
Product Name:1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo-
CAS:899937-47-4
Purity:95% Package:1G,5G,10G,50G,100G,1KG
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(1-(2-((3-chlorophenyl)amino)-2-oxoethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)butanamide
CAS:899937-47-4
Purity:98% Package:1mg;5mg;10mg;25mg;50mg Remarks:BD01620744
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| | 1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- Basic information |
| Product Name: | 1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- | | Synonyms: | 1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo-;N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(1-(2-((3-chlorophenyl)amino)-2-oxoethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)butanamide;N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-[1-[2-[(3-chlorophenyl)amino]-2-oxoethyl]-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl]butanamide;3-[4-[(1,3-Benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo-1(2H)-quinazolineacetamide | | CAS: | 899937-47-4 | | MF: | C28H25ClN4O6 | | MW: | 548.97 | | EINECS: | | | Product Categories: | | | Mol File: | 899937-47-4.mol | ![1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- Structure](CAS/20210305/GIF/899937-47-4.gif) |
| | 1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- Chemical Properties |
| density | 1.419±0.06 g/cm3(Predicted) | | form | Solid | | pka | 13.25±0.70(Predicted) | | color | White to off-white |
| | 1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- Usage And Synthesis |
| Uses | WRX606 is an inhibitor for mTOR complex 1 (mTORC1). WRX606 inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 S6K1 (IC50=10 nM), and the phosphorylation of the eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) (IC50=0.27 μM) in MCF-7. WRX606 exhibits cytotoxicity to HepG2 with IC50 of 17 nM. WRX606 exhibits antitumor efficacy in mouse models[1]. | | References | [1] Shams R, et al., In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC1. J Med Chem. 2022 Jan 27;65(2):1329-1341. DOI:10.1021/acs.jmedchem.1c00536 |
| | 1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- Preparation Products And Raw materials |
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