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Axitinib

Axitinib Suppliers list
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Axitinib
CAS:319460-85-0
Purity:99% Package:117000/KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: inquiry@dakenchem.com
Products Intro: Product Name:Axitinib
CAS:319460-85-0
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Axitinib
CAS:319460-85-0
Purity:98%99% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:319460-85-0
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Axitinib
CAS:319460-85-0

Lastest Price from Axitinib manufacturers

  • Axitinib
  • US $7.00 / KG
  • 2018-08-17
  • CAS: 319460-85-0
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100KG
Axitinib Basic information
FDA approved axitinib use of treating advanced kidney cancer
Product Name:Axitinib
Synonyms:Axitinib (usan);D03218;Axitinib(AG 013736);Axtinib;N-Methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzaMide;Inlyta;10mg;Axitinib (TINIBS)
CAS:319460-85-0
MF:C22H18N4OS
MW:386.47
EINECS:1308068-626-2
Product Categories:Pharmaceuticals;Protein Kinase Inhibitors and Activators;Pfizer compounds;API;AG 013736;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals
Mol File:319460-85-0.mol
Axitinib Structure
Axitinib Chemical Properties
Melting point 213-215°C
density 1.4
storage temp. -20°C Freezer
solubility DMSO: ≥8mg/mL
color white to tan
CAS DataBase Reference319460-85-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,N
Risk Statements 22-50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
MSDS Information
Axitinib Usage And Synthesis
FDA approved axitinib use of treating advanced kidney cancerJanuary 27, 2012, the FDA approved axitinib for the treatment of advanced kidney cancer (renal cell carcinoma) which other drugs unanswer . Inlyta is manufactured and sold by Pfizer,and is a oral pill taken twice a day.
Renal cell carcinoma is a type of tumor originating from the tubular endothelial cells. Axitinib can prevent certain protein called kinases playing a role in tumor growth and metastasis .
Axitinib is a small molecule tyrosine kinase inhibitor, effective against multiple targets, including VEGF receptors 1, 2 and 3.
Dr. Richard Pazdur, hematology and oncology drugs office director of FDA Drug Evaluation and Research Centre, said: "This is the seven kind of drugs allowed treating metastatic or advanced renal cell carcinoma since 2005 . Overall, during this time ,record level of drug development has dramatically changed the treatment of metastatic renal cell carcinoma paradigm, and offers a variety of treatment options for patients. "
In recent years, the drug has been approved for the treatment of kidney cancer include sorafenib (2005), sunitinib (2006), temsirolimus(2007), everolimus (2009), bevacizumab(2009) and pazopanib(2009).
The above information is edited by the chemicalbook of Tian Ye.
Chemical PropertiesOff-White Solid
UsesA tyrosine kinase inhibitor; used in cancer therapy.
UsesAxitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.
UsesAxitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.
UsesAxitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
DefinitionChEBI: An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic tr atment.
Axitinib Preparation Products And Raw materials
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