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2-Acetylbutyrolactone

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Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:2-Acetylbutyrolactone
CAS:517-23-7
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:517-23-7
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Email: info@tnjchem.com
Products Intro: Product Name:2-Acetylbutyrolactone
CAS:517-23-7
Purity:99.9%min. Package:1KG;6USD
Company Name: Hebei Chisure Biotechnology Co., Ltd.
Tel: +8613292890173
Email: luna@speedgainpharma.com
Products Intro: Product Name:2-Acetylbutyrolactone
CAS:517-23-7
Purity:99% Package:1KG;10USD
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:2-Acetylbutyrolactone
CAS:517-23-7
Purity:99% Package:1kg;2USD

Lastest Price from 2-Acetylbutyrolactone manufacturers

  • 2-Acetylbutyrolactone
  • US $2.00 / kg
  • 2019-07-06
  • CAS:517-23-7
  • Min. Order: 10kg
  • Purity: 99%
  • Supply Ability: ask
  • 2-Acetylbutyrolactone
  • US $10.00 / KG
  • 2019-05-06
  • CAS:517-23-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 500tons/month
  • 2-Acetylbutyrolactone
  • US $6.00 / KG
  • 2018-04-04
  • CAS:517-23-7
  • Min. Order: 200KG
  • Purity: 99.9%min.
  • Supply Ability: 10000 tons per year
2-Acetylbutyrolactone Basic information
Description Reference
Product Name:2-Acetylbutyrolactone
Synonyms:2-Acetylbutyrolacton 3-Acetyl-dihydro-2(3H)-furanone;-(-2-Hydroxyethyl)acetoaceticacid-lactone;3-Acetyl-2-(3H)-4,-5-dihydrofuranone;2-Acetyl-4-hydroxybutyric acid gamma-lactone;2-Acetylbutyrolacton;2-Oxo-3-acetyltetrahydrofuran;3-Acetyl-2(3H)-4,5-dihydrofuranone;3-acetyldihydro-2(3h)-furanon
CAS:517-23-7
MF:C6H8O3
MW:128.13
EINECS:208-235-2
Product Categories:ketone;Furan&Benzofuran;Carbonyl Compounds;Lactones;Organic Building Blocks;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Organic solvents
Mol File:517-23-7.mol
2-Acetylbutyrolactone Structure
2-Acetylbutyrolactone Chemical Properties
Melting point <25 °C
Boiling point 107-108 °C5 mm Hg(lit.)
density 1.19 g/mL at 25 °C(lit.)
refractive index n20/D 1.459(lit.)
Fp >230 °F
storage temp. -20?C Freezer, Under Inert Atmosphere
solubility 200g/l
pka12.00±0.20(Predicted)
form Liquid
color Clear
Water Solubility 310 g/L (20 ºC)
Merck 14,83
BRN 112676
Stability:Stable. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference517-23-7(CAS DataBase Reference)
NIST Chemistry Reference2(3H)-Furanone, 3-acetyldihydro-(517-23-7)
EPA Substance Registry System2(3H)-Furanone, 3-acetyldihydro- (517-23-7)
Safety Information
Hazard Codes Xi,T
Risk Statements 36/37/38-61
Safety Statements 26-36-37/39-45-53
WGK Germany 1
RTECS LU3456000
TSCA Yes
HS Code 29322980
MSDS Information
ProviderLanguage
ABL English
SigmaAldrich English
ACROS English
ALFA English
2-Acetylbutyrolactone Usage And Synthesis
DescriptionIt is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methylthiazole. In presence of 2-acetylbutyrolactone, reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates leads to the formation of dialkyl (E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates.1 Moreover, reaction of 2-acetylbutyrolactone with thiosemicarbazide and 3-(2-bromo-acetyl)-chromen-2-one in anhydrous ethanol produced 3-{2-[5-hydroxyl-4-(2-hydroxyl-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-one in good yields.2 In addition, 2-acetylbutyrolactone can also function as the raw material for synthesizing pilocarpine that is a leading therapeutic agent for the treatment of narrow and wide angle glaucoma.3 Besides, this chemical can also act as a fluorogenic reagent in the quantitative spectrofluorometric determination of primary amines, which has been demonstrated to be equally accurate and precise as the officially or other reported methods.4
Reference
  1. Asghari, S.; Mohammadi, L., Reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates in the presence of 2-acetylbutyrolactone. Synthesis of functionalized alpha-methylene-gamma-butyrolactones. Tetrahedron Lett. 2006, 47, 4297-4299.
  2. Rao, V. R.; Kumar, P. V., Facile one-pot synthesis of 3-{25-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-pyrazol-1-yl -thiazol-4-yl} -chromen-2-ones via a three-component reaction. Synth. Commun. 2006, 36, 2157-2161.
  3. Horne, D. A.; Fugmann, B.; Yakushijin, K.; Buchi, G., A SYNTHESIS OF PILOCARPINE. J. Org. Chem. 1993, 58, 62-64.
  4. Sabry, S. M., Application of 2-acetylbutyrolactone to spectrofluorinietry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. J. Pharm. Biomed. Anal. 2006, 40, 1057-1067.
Chemical PropertiesColorless to light yellow liqui
UsesAn intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.
UsesIn synthesis of 3,4-disubstituted pyridines; of 5-(b-hydroxethyl)-4-methylthiazole.
Tag:2-Acetylbutyrolactone(517-23-7) Related Product Information
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