|
|
| | CYCLO(ARG-GLY-ASP-D-PHE-VAL) Basic information |
| Product Name: | CYCLO(ARG-GLY-ASP-D-PHE-VAL) | | Synonyms: | RGDFV PEPTIDE, CYCLIC;Cyclo(Arg-Gls-Asp-D-Phe-Val);EMD 66203, c(RGDfV);CYCLO(ARG-GLY-ASP-D-PHE-VAL);CYCLO(RGDD-FV);cRGDfV;EMD 66203;Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt | | CAS: | 137813-35-5 | | MF: | C26H38N8O7 | | MW: | 574.63 | | EINECS: | | | Product Categories: | | | Mol File: | 137813-35-5.mol |  |
| | CYCLO(ARG-GLY-ASP-D-PHE-VAL) Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | form | White solid | | pka | 4.01±0.10(Predicted) |
| | CYCLO(ARG-GLY-ASP-D-PHE-VAL) Usage And Synthesis |
| General Description | Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation. | | Biochem/physiol Actions | Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates |
| | CYCLO(ARG-GLY-ASP-D-PHE-VAL) Preparation Products And Raw materials |
|