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| | 1-(4-BROMOPHENYL)PYRROLIDINE Basic information |
| Product Name: | 1-(4-BROMOPHENYL)PYRROLIDINE | | Synonyms: | 1-(4-BROMOPHENYL)PYRROLIDINE;N-(4-BROMOPHENYL)PYRROLIDINE;Pyrrolidine, 1-(4-broMophenyl)-;1-Bromo-4-pyrrolidinobenzene;1-(4-Bromophenyl)pyrrolidine 97+%;1-(4-Bromophenyl)pyrrolidine > | | CAS: | 22090-26-2 | | MF: | C10H12BrN | | MW: | 226.11 | | EINECS: | | | Product Categories: | Miscellaneous | | Mol File: | 22090-26-2.mol |  |
| | 1-(4-BROMOPHENYL)PYRROLIDINE Chemical Properties |
| Melting point | 105.0 to 109.0 °C | | Boiling point | 306.1±25.0 °C(Predicted) | | density | 1.411±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | powder to crystal | | pka | 4.81±0.40(Predicted) | | color | White to Almost white |
| | 1-(4-BROMOPHENYL)PYRROLIDINE Usage And Synthesis |
| Synthesis | Step 82a: Synthesis of 1-(4-bromophenyl)pyrrolidine (compound 0601-155)
A mixture of 4-bromoaniline (1 g, 5.81 mmol), Cs2CO3 (5.68 g, 17.44 mmol), and 1,4-dibromobutane (1.88 g, 8.72 mmol) was dissolved in DMF (20 mL), and the reaction was stirred at 60 °C overnight. After completion of the reaction, the mixture was cooled to room temperature, diluted with water (200 mL) and extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, washed sequentially with water (3 x 100 mL) and brine (100 mL) and dried over anhydrous Na2SO4. After concentration under reduced pressure, purified by silica gel column chromatography (eluent: petroleum ether), the target compound 0601-155 (720 mg, 46% yield) was obtained as a colorless oil.LCMS: 226 [M + 1]+.1H NMR (400MHz, DMSO-d6) δ1.94 (t, J=6.4Hz, 4H), 3.18 (t, J=6.4Hz, 4H), 6.18 (t, J=6.4Hz, 4H). Hz, 4H), 6.47 (d, J=9.2Hz, 2H), 7.27 (d, J=9.2Hz, 2H). | | References | [1] Journal of the American Chemical Society, 2014, vol. 136, # 33, p. 11602 - 11605
[2] Journal of Organic Chemistry, 2006, vol. 71, # 1, p. 135 - 141
[3] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 221
[4] Patent: US2013/102595, 2013, A1. Location in patent: Paragraph 0550
[5] Patent: JP2015/187145, 2015, A. Location in patent: Paragraph 0468 |
| | 1-(4-BROMOPHENYL)PYRROLIDINE Preparation Products And Raw materials |
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