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| | Ethyl2,6-PyridinedicarboxylateMono Basic information |
| Product Name: | Ethyl2,6-PyridinedicarboxylateMono | | Synonyms: | 6-Ethoxycarbonyl-2-pyridinecarboxylic acid;Methyl dipicolinate;2,6-pyridinediCarbocylic acid monoethyl ester;6-(Ethoxycarbonyl);Ethyl2,6-PyridinedicarboxylateMono;2,6-pyridinedicarboxylatemonoethylester;6-(Ethoxycarbonyl)picolinic acid;2,6-Pyridinedicarboxylic acid, 2-ethyl ester | | CAS: | 21855-16-3 | | MF: | C9H9NO4 | | MW: | 195.17 | | EINECS: | | | Product Categories: | | | Mol File: | 21855-16-3.mol |  |
| | Ethyl2,6-PyridinedicarboxylateMono Chemical Properties |
| Melting point | 116-117℃ | | Boiling point | 396.2±27.0 °C(Predicted) | | density | 1.304±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 3.27±0.10(Predicted) | | Appearance | White to off-white Solid |
| | Ethyl2,6-PyridinedicarboxylateMono Usage And Synthesis |
| Synthesis | The general synthetic procedure was as follows. 2,6-Pyridinedicarboxylic acid (1, 1.5 g, 8.98 mmol) was mixed with 24 mL of dichlorosulfoxide (SOCl2). The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, excess dichlorosulfoxide was removed by distillation under reduced pressure. To the resulting white solid, 50 mL of tetrahydrofuran (THF) was added. After the solid was completely dissolved, ethanol (10.5 mmol) and N,N-diisopropylethylamine (DIEA, 10.5 mmol) were added slowly via syringe. The reaction mixture was heated to reflux for 4 hours. At the end of the reaction, the solvent was removed by distillation under reduced pressure. The residue was separated and purified by column chromatography to afford the target products diethyl 2,6-pyridinedicarboxylate and monoethyl 2,6-pyridinedicarboxylate. | | References | [1] Tetrahedron, 2011, vol. 67, # 44, p. 8458 - 8464 |
| | Ethyl2,6-PyridinedicarboxylateMono Preparation Products And Raw materials |
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