吡考拉唑
| 中文名称 | 吡考拉唑 |
|---|---|
| 中文同义词 | 吡考拉唑;化合物 T12471 |
| 英文名称 | Picoprazole |
| 英文同义词 | 6-Methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-5-carboxylic acid methyl ester;H-149/94;5-methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-Benzimidazole-6-carboxylic acid Methyl ester;Picoprazole;1H-Benzimidazole-6-carboxylic acid, 5-methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-, methyl ester;1H-Indene-1,3(2H)-dione,5,7-dichloro- |
| CAS号 | 78090-11-6 |
| 分子式 | C17H17N3O3S |
| 分子量 | 343.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 78090-11-6.mol |
| 结构式 |  |
吡考拉唑 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
IC50: 3.1±0.4 μM (H + /K + -ATPase)
Picoprazole inhibits the H + /K + -ATPase activity in a concentration-dependent manner. The IC 50 value is 3.1±0.4 μM. Picoprazole is a specific inhibitor of H + /K + -ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl - conductance by Cu 2+ -o-phenanthroline, indicating that the Cl - conductance is part of the function of the H + /K + -ATPase. The inhibitory effect of the three benzimidazole derivatives Timoprazole, Picoprazole, and Omeprazole on histamine and dbcAMP stimulated 14 C-aminopyrine accumulation (H + secretion) has been studied in isolated and enriched guinea-pig parietal cells. All compounds tested inhibit H + secretion in a concentration dependent manner with IC 50 values of 8.5±1.9 μM for Timoprazole, 3.9±0.7 μM for Picoprazole, and 0.13±0.03 μM for Omeprazole.