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Moxonidine

Moxonidine Suppliers list
Company Name: Shaanxi TNJONE Pharmaceutical Co., Ltd
Tel: +86-17396673057
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Products Intro: Product Name:Moxonidine
CAS:75438-57-2
Purity:99% Package:1kg
Company Name: Wuhan Chemwonders Technology Inc.
Tel: 027-85778276
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Products Intro: Product Name:Moxonidine
CAS:75438-57-2
Purity:99.5% Package:25kg per barrel Remarks:pharmaceutical intermediates
Company Name: Synbest Biotech(Hangzhou) Co., Ltd
Tel: 86-571-88737065
Email: sales@synbestech.com
Products Intro: Product Name:Moxonidine
CAS:75438-57-2
Purity:99% HPLC Package:1KG,10KG,100KG,1000KG
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
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Products Intro: Product Name:Moxonidine
CAS:75438-57-2
Purity:99% Package:1g;1USD
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-29-87569266 15319487004
Email: 1015@dideu.com
Products Intro: Product Name:Moxonidine
CAS:75438-57-2
Purity:99.0% Package:100g;1kg;5kg;25kg

Moxonidine manufacturers

  • Moxonidine
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  • $0.00 / 1Kg/Bag
  • 2025-05-29
  • CAS:75438-57-2
  • Min. Order: 50g
  • Purity: 97.5%-102%
  • Supply Ability: 1000g
  • Moxonidine
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  • $33.00 / 100mg
  • 2025-05-28
  • CAS:75438-57-2
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  • Purity: 99.94%
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  • Moxonidine
  • Moxonidine pictures
  • $33.00 / 100mg
  • 2025-05-28
  • CAS:75438-57-2
  • Min. Order:
  • Purity: 99.94%
  • Supply Ability: 10g
Moxonidine Basic information
Description Physical and Chemical Properties Application Preparation Precautions References
Product Name:Moxonidine
Synonyms:MOXONIDINE;MOXONIDINE HCL;4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamin;bdf5895;be5895;BDF-5895 HCL;4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL;4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE
CAS:75438-57-2
MF:C9H12ClN5O
MW:241.68
EINECS:629-833-3
Product Categories:Cardiovascular APIs;API;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API's
Mol File:75438-57-2.mol
Moxonidine Structure
Moxonidine Chemical Properties
Melting point 217-219° (dec)
Boiling point 364.7±52.0 °C(Predicted)
density 1.52±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
form Solid
pka7.11±0.10(Predicted)
color White to Almost white
Water Solubility 800.3mg/L(temperature not stated)
Merck 14,6293
InChIKeyWPNJAUFVNXKLIM-UHFFFAOYSA-N
CAS DataBase Reference75438-57-2(CAS DataBase Reference)
Safety Information
RIDADR UN 2811 6.1/PG III
WGK Germany 3
RTECS UV6260290
HS Code 2933.99.5300
HazardClass 6.1
PackingGroup III
MSDS Information
ProviderLanguage
Moxonidine English
SigmaAldrich English
Moxonidine Usage And Synthesis
DescriptionMoxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.
Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.
It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity.
It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.
Physical and Chemical Propertiesensity: 1.52g/cm3, boiling point:  364.7 °C at 760 mmHg, flash point: 174.3 °C, crystallization, melting point: 217-219 degrees Celsius.
Application
  • By stimulating the central presynaptic alpha 2-receptor and onset, and its antihypertensive effect of ACE inhibitors, calcium antagonists nifedipine and captopril similar. Treatment of essential hypertension.
  • The intervention of renal interstitial fibrosis can protect the kidney.
Preparation5-amino-4,6-dichloro-2-methyl pyrimidine and 1-acetyl-2-imidazolin-2-one. The product, reacting with sodium methanol can produce moxonidine.
Precautions
  • There may be dry mouth, fatigue and headache at the beginning of treatment, occasional dizziness, insomnia, and weakness in the legs and so on.
  • Sick sinus syndrome, the sinus node and atrioventricular Ⅱ-Ⅲ degree block, resting bradycardia (50 beats/min), unstable angina, severe liver disease, progressive renal dysfunction, angioedema patients should not use it.
Referenceshttps://en.wikipedia.org/wiki/Moxonidine
DescriptionMoxonidine, which is structurally related to clonidine, is a new centrally acting antihypertensive that acts as a stronger agonist at imidazole receptors and a weaker agonist at α2-adrenergic receptors than clonidine. It is also reported to have less side effects and a much reduced potential to produce a rebound in blood pressure on withdrawal. Clinically, moxonidine appears to have comparable antihypertensive efficacy with the ACE inhibitors and calcium antagonists.
Chemical PropertiesWhite Solid
OriginatorBeiersdorf (Germany)
UsesAntihypertensive;Imidazoline receptor agonist
UsesMoxonidine is an antihypertensive agent.
DefinitionChEBI: Moxonidine is an organohalogen compound and a member of pyrimidines.
Brand nameCynt (Lilly); Nucynt (Lilly); Norcynt (Lilly);Physiotens.
Biological ActivityMixed I 1 imidazoline receptor and α 2 -adrenergic agonist; displays 40-fold higher affinity for I 1 receptors versus α 2 -adrenoceptors. Centrally acting antihypertensive agent.
Clinical UseAntihypertensive agent (centrally acting agonist at I1 receptor, imidazoline and alpha2 adrenoceptors)
Metabolism10-20% metabolised, predominantly to 4,5-dehydromoxonidine and to an aminomethanamidine derivative both of which are much less active than moxonidine. Moxonidine and its metabolites are almost entirely eliminated via the kidney. More than 90% of the dose is eliminated in the first 24 hours via the kidney, while approximately 1% is eliminated in the faeces
Moxonidine Preparation Products And Raw materials
Raw materialsEthylenediamine-->Ammonium thiocyanate-->4,5-dihydro-1H-imidazole-->4,6-Dichloro-2-methylpyrimidine
Tag:Moxonidine(75438-57-2) Related Product Information
(Trifluoromethoxy)benzene 1-Methylimidazole MOXONIDINE HYDROCHLORIDE,MOXONIDINE HCL 5-METHYLCYTOSINE Pirimiphos-methyl Mestinon Bendazac L-lysine Losartan potassium Fursultiamine Terazosin Lovastatin 4-chloro-6-methoxy-2-methyl-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)pyrimidin-5-amine 5-Amino-4,6-dichloro-2-methylpyrimidine 4-chloro-6-methoxy-2-methylpyrimidin-5-amine 4-Chloro-6-methoxypyrimidine Imidazole Pyrimidine 6-Chloropyrimidin-4(3H)-one

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