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Moxonidine

Moxonidine Suppliers list
Company Name: Wuhan Chemwonders Technology Inc.
Tel: 027-85778276
Email: info@chemwonders.com
Products Intro: Product Name:Moxonidine
CAS:75438-57-2
Purity:99.5% Package:25kg per barrel Remarks:pharmaceutical intermediates
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:Moxonidine;BDF5895 fandachem
CAS:75438-57-2
Purity:As coa Package:As request Remarks:75438-57-2
Company Name: Guangzhou PI PI Biotech Inc
Tel: ;
Email: sales@pipitech.com;87478684@qq.com
Products Intro: Product Name:Moxonidine
CAS:75438-57-2
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:4-Chloro-N-(imidazolidin-2-ylidene)-6-methoxy-2-methylpyrimidin-5-amine.
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: 08657186217390
Email: sales@gihichemicals.com
Products Intro: Product Name:Moxonidine
CAS:75438-57-2
Purity:98% HPLC Package:5g/bag;100g/bag;1kg/bag;5kg/bag;25kg/bag
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Email: info@hnbon.com
Products Intro: CAS:75438-57-2
Purity:0.99 Package:25KG;5KG;1KG;500G

Lastest Price from Moxonidine manufacturers

  • Moxonidine
  • US $100.00 / KG
  • 2021-10-20
  • CAS:75438-57-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 9000kg/per week
  • Moxonidine
  • US $0.00 / Kg/Bag
  • 2021-09-29
  • CAS:75438-57-2
  • Min. Order: 50g
  • Purity: 97.5%-102%
  • Supply Ability: 1000g
  • Moxonidine USP/EP/BP
  • US $1.10 / g
  • 2021-08-11
  • CAS:75438-57-2
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
Moxonidine Basic information
Description Physical and Chemical Properties Application Preparation Precautions References
Product Name:Moxonidine
Synonyms:MOXONIDINE;MOXONIDINE HCL;4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamin;bdf5895;be5895;BDF-5895 HCL;4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL;4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE
CAS:75438-57-2
MF:C9H12ClN5O
MW:241.68
EINECS:629-833-3
Product Categories:Cardiovascular APIs;API;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API's
Mol File:75438-57-2.mol
Moxonidine Structure
Moxonidine Chemical Properties
Melting point 217-219° (dec)
Boiling point 364.7±52.0 °C(Predicted)
density 1.52±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
form neat
pka7.11±0.10(Predicted)
Water Solubility 800.3mg/L(temperature not stated)
Merck 14,6293
InChIKeyWPNJAUFVNXKLIM-UHFFFAOYSA-N
CAS DataBase Reference75438-57-2(CAS DataBase Reference)
Safety Information
RIDADR UN 2811 6.1/PG III
WGK Germany 3
RTECS UV6260290
HazardClass 6.1
PackingGroup III
MSDS Information
ProviderLanguage
Moxonidine English
SigmaAldrich English
Moxonidine Usage And Synthesis
DescriptionMoxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.
Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.
It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity.
It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.
Physical and Chemical Propertiesensity: 1.52g/cm3, boiling point:  364.7 °C at 760 mmHg, flash point: 174.3 °C, crystallization, melting point: 217-219 degrees Celsius.
Application
  • By stimulating the central presynaptic alpha 2-receptor and onset, and its antihypertensive effect of ACE inhibitors, calcium antagonists nifedipine and captopril similar. Treatment of essential hypertension.
  • The intervention of renal interstitial fibrosis can protect the kidney.
Preparation5-amino-4,6-dichloro-2-methyl pyrimidine and 1-acetyl-2-imidazolin-2-one. The product, reacting with sodium methanol can produce moxonidine.
Precautions
  • There may be dry mouth, fatigue and headache at the beginning of treatment, occasional dizziness, insomnia, and weakness in the legs and so on.
  • Sick sinus syndrome, the sinus node and atrioventricular Ⅱ-Ⅲ degree block, resting bradycardia (50 beats/min), unstable angina, severe liver disease, progressive renal dysfunction, angioedema patients should not use it.
Referenceshttps://en.wikipedia.org/wiki/Moxonidine
DescriptionMoxonidine, which is structurally related to clonidine, is a new centrally acting antihypertensive that acts as a stronger agonist at imidazole receptors and a weaker agonist at α2-adrenergic receptors than clonidine. It is also reported to have less side effects and a much reduced potential to produce a rebound in blood pressure on withdrawal. Clinically, moxonidine appears to have comparable antihypertensive efficacy with the ACE inhibitors and calcium antagonists.
Chemical PropertiesWhite Solid
OriginatorBeiersdorf (Germany)
UsesMoxonidine is an antihypertensive agent.
UsesAntihypertensive;Imidazoline receptor agonist
Brand nameCynt (Lilly); Nucynt (Lilly); Norcynt (Lilly);Physiotens.
Biological ActivityMixed I 1 imidazoline receptor and α 2 -adrenergic agonist; displays 40-fold higher affinity for I 1 receptors versus α 2 -adrenoceptors. Centrally acting antihypertensive agent.
Moxonidine Preparation Products And Raw materials
Raw materialsEthylenediamine-->Ammonium thiocyanate-->4,5-dihydro-1H-imidazole-->4,6-Dichloro-2-methylpyrimidine
Tag:Moxonidine(75438-57-2) Related Product Information
MOXONIDINE HYDROCHLORIDE,MOXONIDINE HCL Mestinon Bendazac L-lysine Losartan potassium Fursultiamine Terazosin Lovastatin 4-chloro-6-methoxy-2-methyl-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)pyrimidin-5-amine 5-METHYLCYTOSINE Pyrimidine MOXONIDINE IMPURITY A 5-amino-4,6-dichloro-2-methyl pyrimidine (intermediate of moxonidine) 5-Amino-4,6-dichloro-2-methylpyrimidine Moxonidine Condensation Compound 4,6-dichloro-5-(1-acetyl-2-imidazoline-2-amino)-2-methylpyrimidine (intermediate of moxonidine hcl) 5-Pyrimidinamine, 4-methoxy- (9CI) 4(1H)-Pyrimidinone, 6-chloro-2-methyl- (9CI) 5-Pyrimidinamine, N-methyl- (9CI)