ChemicalBook > Product Catalog >API >Digestive system drugs >Antacid and Mucosal protective Drugs >Pantoprazole


Pantoprazole Suppliers list
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;
Products Intro: CAS:102625-70-7
Purity:98% Package:g-Kg Remarks:White powder
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Products Intro: Product Name:pantoprazole
Purity:99% Package:5KG;1KG Remarks:C16H15F2N3O4S
Company Name: BOC Sciences
Tel: 1-631-485-4226
Products Intro: Product Name:Pantoprazole
Tel: 0371-55170695
Products Intro: CAS:102625-70-7
Purity:0.99 Package:25KG;5KG;1KG;500G
Tel: 86-18523575427
Products Intro: Product Name:pantoprazole
Purity:0.99 Package:1kg

Pantoprazole manufacturers

  • Pantoprazole
  • $1.00 / g
  • 2021-11-08
  • CAS:102625-70-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 30 Tons
  • Pantoprazole
  • $444.00 / Kg/Bag
  • 2021-11-02
  • CAS:102625-70-7
  • Min. Order: 1Kg/Bag
  • Purity: 99%
  • Supply Ability: 20T
  • pantoprazole
  • $50.00 / KG
  • 2021-08-31
  • CAS:102625-70-7
  • Min. Order: 1Kg/Bag
  • Purity: 99.99%
  • Supply Ability: 20 tons/month
Pantoprazole Basic information
Product Name:Pantoprazole
Synonyms:5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-yridinyl)methyl]sulfinyl]-1h-benzimidazole;5-(DIFLUOROMETHOXY)-2-[[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZIMIDAZOLE;6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1h-benzimidazole;PANTOPRAZOLE;PANTOPRAZOLE SODIUM 98-102%;Pantoprazole (base and/or unspecified salts);Pantoprazole&Int.;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-3H-benzoimidazole
Product Categories:Isotopically Labeled Pharmaceutical Reference Standard;PROTONIX;ACTIVE PHARMACEUTICAL INGREDIENTS;APIs;Pantoprazole;Metabolite Reference Standard;API's
Mol File:102625-70-7.mol
Pantoprazole Structure
Pantoprazole Chemical Properties
Melting point 139-140° (dec)
Boiling point 586.9±60.0 °C(Predicted)
density 1.51±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
pkapKa1 3.92; pKa2 8.19(at 25℃)
CAS DataBase Reference102625-70-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-37/38-41-48
Safety Statements 22-26-36/37/39-45
Hazardous Substances Data102625-70-7(Hazardous Substances Data)
MSDS Information
Pantoprazole Usage And Synthesis
DescriptionPantoprazole, an irreversible proton pump inhibitor, reached its first market worldwide in Germany for acute treatment of gastric and duodenal ulcers and gastroesophageal reflux disease. Proton pump inhibitors are more effective than other strategies in inhibiting acid secretion since they function at the final step of acid production, therefore, provide superior symptom relief and healing in all acid related diseases. As the third substituted benzimidazole proton pump inhibitor marketed, pantoprazole not only has superior ulcer-preventing effect but also is more potent than omeprazole in healing acetic acid-induced gastric and duodenal ulcers with extremely low acute toxicity. The mechanism of action for this class of compounds has been suggested to be mediated via the protonated form of the molecule which selectively reacts with cysteines present on the extracytoplasmic face of the enzyme to form covalent disulfide bonds.
OriginatorByk Gulden (Germany)
Usesproton pump inhibitor, gastric acid release inhibitor, antiulcer
DefinitionChEBI: A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2.
Manufacturing Process2-Chloromethyl-4,5-dimethoxy-3-methylpyridinium chloride (about 1.5 g) are added to a solution of 5-difluoromethoxy-1H-benzimidazole-2-thiol in 10 ml of ethanol and 10 ml of 1 N sodium hydroxide solution. The yellow reaction mixture is stirred at 20°C for 1 hour, a further 10 ml of water are added, whereupon a colorless solid precipitates out, the mixture is stirred for a further 5 hours and filtered and the residue is rinsed with 1 N sodium hydroxide solution and water and dried to constant weight. The 5difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole is obtained as an oil.
5-Difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole (about 1 g) are dissolved in 10 ml of dioxane and 2 ml of 1 N sodium hydroxide solution. An equimolar amount of a titrated aqueous sodium hypochlorite solution, to which 1 mole per liter of sodium hydroxide solution has been added, is first added dropwise, while cooling with ice. After one hour a further equivalent and after 3 hours half the equimolar amount of sodium hypochlorite are added, to achieve complete reaction. After a reaction time of 4 hours, 5 ml of 5% strength sodium thiosulfate solution and another 25 ml of dioxane are added and the upper dioxane phase is separated off, washed once with 5 ml of sodium thiosulfate solution and concentrated on a rotary evaporator. The oily residue is dissolved in 20 ml of water and 10 ml of ethyl acetate and the solution is brought to pH 7 with about 100 ml of a buffer solution of pH 6.8. The solid which has precipitated out is filtered off with suction over a suction filter, washed with water, extracted by stirring at 0C with acetone and dried. 5-Difluoromethoxy-2-[(4,5-dimethoxy-2pyridyl)methanesulfinyl]-1H-benzimidazole is prepared; yield about 85%.
Brand namePantozol; Rifun
Therapeutic FunctionAntiulcer
Veterinary Drugs and TreatmentsPantoprazole may be useful in treating or preventing gastric acidrelated pathologies in dogs, cats, foals and camelids, particularly when the intravenous route is preferred. Pantoprazole is available in both intravenous and oral tablet (delayed-release) formulations. One study (Bersenas, Mathews et al. 2005) performed in dogs, comparing the gastric pH effects of intravenous pantoprazole with oral omeprazole, intravenous ranitidine, and intravenous famotidine, found at the dosages used, that pantoprazole was more effective than ranitidine, but similar to famotidine, and that oral omeprazole was more effective in maintaining intragastric pH >3 for a longer period than pantoprazole.
Pantoprazole has been shown to directly reduce in vitro counts of H. pylori and is used in some H. pylori treatment protocols for humans.
Tag:Pantoprazole(102625-70-7) Related Product Information
Rabeprazole R-(+)-Lansoprazole Pantoprazole Sodium PANTOPRAZOLE SULPHONE SODIUM SALT Omeprazole Pantoprazole sodium Sesqu Hydrate Pantoprazole Impurity,Pantoprazole Sulfide N-Oxide (Pantoprazole Impurity) see P183030,Pantoprazole Sulfide N-Oxide (Pantoprazole Impurity) Pantoprazole Sodium Pellets Pantoprazole sodium sterile PANTOPRAZOLE SULPHONE N-OXIDE S-Pantoprazole PANTOPRAZOLE SULFIDE-B-D-GLUCURONIDE,Pantoprazole Sulfide--D-glucuronide PANTOPRAZOLE-D3 O-DESMETHYL PANTOPRAZOLE O-SULFATE 2-CHLOROMETHYL-3,4-DIMETHOXY PYRIDINE HYDROCHLORIDE Pantoprazole Pellets PANTOPRAZOLE SULFONE N-OXIDE PANTOPRAZOLE DEUTERATED, SODIUM SALT