| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Company Name: |
Creative Enzymes |
| Tel: |
1-516-855-7709 |
| Email: |
info@creative-enzymes.com |
|
| | rhodopsin kinase Basic information |
| Product Name: | rhodopsin kinase | | Synonyms: | Anti-GRK1, N-Terminal antibody produced in rabbit;rhodopsin kinase;kinase GRK1;RHOK;RK;GPRK1;GRK1, active, GST tagged human;EXIP | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![rhodopsin kinase Structure]() |
| | rhodopsin kinase Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous glycerol solution | | Specific Activity | 3.6-4.9nmol/min·mg |
| WGK Germany | WGK 1 | | Storage Class | 10 - Combustible liquids |
| | rhodopsin kinase Usage And Synthesis |
| Uses | GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases. GRK1 mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin which leads to its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). GRK1 can be phosphorylated by PKA and this reduces the ability of GRK1 to phosphorylate rhodopsin in vitro. It is speculated that phosphorylation of GRK1 by PKA in vivo occurs in the dark when cAMP levels in photoreceptor cells are elevated. |
| | rhodopsin kinase Preparation Products And Raw materials |
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