三角叶薯蓣皂苷
| 中文名称 | 三角叶薯蓣皂苷 |
|---|---|
| 中文同义词 | 三角叶薯蓣皂甙;三角叶薯蓣皂苷;三角叶薯蓣皂苷标准品;三角叶薯蓣皂苷对照品 |
| 英文名称 | deltonin |
| 英文同义词 | deltonin;3-O-beta-D-Glucopyranosyl(1-4)-[alpha-L-rhamnopyranosyl(1-2)]-beta-D-glucopyranoside-diosgenin;Deltonin,3-O-β-D-Glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside-diosgenin;β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-;Deltonin,Akt,Protein kinase B,PKB,Inhibitor,Extracellular signal regulated kinases,inhibit,ERK,Endogenous Metabolite |
| CAS号 | 55659-75-1 |
| 分子式 | C45H72O17 |
| 分子量 | 885.04 |
| EINECS号 | |
| 相关类别 | 标准品;分析试剂标准品;对照品;标准品，对照品 |
| Mol文件 | 55659-75-1.mol |
| 结构式 |  |
三角叶薯蓣皂苷 性质
| 熔点 | 298-300 °C (decomp) |
|---|---|
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light |
| 酸度系数(pKa) | 12?+-.0.70(Predicted) |
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ERK1
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ERK2
|
Akt
|
Human Endogenous Metabolite
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Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC 50 s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells. Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA‑MB‑231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA‑MB‑231 cells.
Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N2283 | Deltonin | 1 mg | 1520元 | |
| 2024/01/25 | HY-N2283 | 三角叶薯蓣皂苷 Deltonin | 55659-75-1 | 5mg | 3800元 |