| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:ER degrader 7
CAS:2922929-63-1
Package:5mg;50mg
|
ER degrader 7 manufacturers
- ER degrader 7
-
- $0.00 / 5mg
-
2025-10-27
- CAS:2922929-63-1
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | ER degrader 7 Basic information |
| Product Name: | ER degrader 7 | | Synonyms: | ER degrader 7;Selenocyanic acid, 6-[[4-[6-[[(2-fluorophenyl)(2,2,2-trifluoroethyl)amino]sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenyl]amino]-6-oxohexyl ester | | CAS: | 2922929-63-1 | | MF: | C33H31F4N3O5SSe | | MW: | 736.64 | | EINECS: | | | Product Categories: | | | Mol File: | 2922929-63-1.mol |  |
| | ER degrader 7 Chemical Properties |
| pka | 10.129±0.30(predicted) |
| | ER degrader 7 Usage And Synthesis |
| Uses | ER degrader 7 (Compound 35t) is an ERα and ERβ degrader. ER degrader 7 inhibits tubulin polymerization. ER degrader 7 inhibits cell viability with IC50s of 0.06, 2.56, 15.84, 1.59, 1.67, 1.37 μM for MCF-7, T47D, MCF-10A, LCC2, T47D D538G, and T47D Y537S cells respectively. ER degrader 7 also inhibits breast cancer tumor growth[1]. | | References | [1] Deng X, et al. Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer. J Med Chem. 2023 Aug 24;66(16):11094-11117. DOI:10.1021/acs.jmedchem.3c00465 |
| | ER degrader 7 Preparation Products And Raw materials |
|