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| | TCPOBOP Basic information |
| Product Name: | TCPOBOP | | Synonyms: | 3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE;3,3',5,5'-TETRACHLORIDE-BPB;1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE;TCPOBOP;2,2’-(1,4-phenylenebis(oxy))bis(3,5-dichloro-pyridin;1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene, 3,3μ,5,5μ-Tetrachloro-1,4-bis(pyridyloxy)benzene;1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene;1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene | | CAS: | 76150-91-9 | | MF: | C16H8Cl4N2O2 | | MW: | 402.06 | | EINECS: | | | Product Categories: | | | Mol File: | 76150-91-9.mol |  |
| | TCPOBOP Chemical Properties |
| Boiling point | 444.8±45.0 °C(Predicted) | | density | 1.518±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >10 mg/mL | | form | solid | | pka | -0.52±0.10(Predicted) | | color | white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | UT7145000 |
| | TCPOBOP Usage And Synthesis |
| Description | TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis. | | Uses | TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins. | | General Description | A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver. | | Biochem/physiol Actions | TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents. | | References | 1) Tzameli et al. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR; Mol. Cell. Biol., 20 2951
2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine; Carcinogenesis, 13 1893 |
| | TCPOBOP Preparation Products And Raw materials |
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