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Bethanechol

Bethanechol Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:Bethanechol
CAS:590-63-6
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:bethanechol chloride
CAS:590-63-6
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:590-63-6
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;product@chemlin.com.cn
Email: product@chemlin.com.cn
Products Intro: CAS:590-63-6
Purity:USP36 Package:g-Kg Remarks:White crystal powder
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Email: bruce@xrdchem.cn
Products Intro: Product Name:Bethanechol
CAS:590-63-6
Purity:99% Package:100g/ bag, 2 kg/ bag, 25kg/ carton or as required Remarks:white crystalline

Bethanechol manufacturers

  • Bethanechol
  • $10.50 / KG
  • 2021-12-01
  • CAS:590-63-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10 ton
  • Bethanechol
  • $10.00 / KG
  • 2021-10-22
  • CAS:590-63-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 5tons
  • Bethanechol chloride
  • $1.00-499.00 / g
  • 2021-10-21
  • CAS:590-63-6
  • Min. Order: 0.5KG
  • Purity: >99%
  • Supply Ability: 20tons
Bethanechol Basic information
Product Name:Bethanechol
Synonyms:(2-hydroxypropyl)trimethylammoniumchloridecarbamate;2-((aminocarbonyl)oxy)-n,n,n-trimethyl-1-propanaminiuchloride;2-[(aminocarbonyl)oxy]-n,n,n-trimethyl-1-propanaminiuchloride;ammonium,(2-hydroxypropyl)trimethyl-,chloride,carbamate;beta-methylcholinechlorideurethan;bethainecholinechloride;carbaminoyl,beta-methylcholinechloride;carbamyl-b-methylcholinechloride*crystalline
CAS:590-63-6
MF:C7H17ClN2O2
MW:196.68
EINECS:209-686-8
Product Categories:Coumarins ,Pyrans;Inhibitors;Acetylcholine receptor;Aliphatics;Amines;DUVOID;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:590-63-6.mol
Bethanechol Structure
Bethanechol Chemical Properties
Melting point 187-190°C
storage temp. Inert atmosphere,2-8°C
solubility H2O: 1.7 g/mL stable for several days at 4°C.
form crystalline
color white
Merck 14,1185
CAS DataBase Reference590-63-6(CAS DataBase Reference)
EPA Substance Registry System1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride (590-63-6)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
WGK Germany 3
RTECS BR5425000
TSCA Yes
HS Code 2924190002
MSDS Information
ProviderLanguage
SigmaAldrich English
Bethanechol Usage And Synthesis
Chemical PropertiesWhite Solid
OriginatorUrecholine CI,MSD,US,1949
Usescholinergic
UsesA selective muscarinic receptor stimulant, used to treat cerebral palsy.
UsesTherapeutic action of Betanechol is based on this action, and it is used for treating postoperational non-obstructive retention of urine and neurogenic bladder atony. Earlier, it was used for treating gastrointestinal illnesses and Alzheimer’s disease.
DefinitionChEBI: The chloride salt of bethanechol. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
Manufacturing ProcessAbout 3 grams of β-methylcholine chloride are stirred at room temperature with an excess of phosgene dissolved in 50 grams of chloroform, for about 2 hours. Excess phosgene and hydrochloric acid are removed by distillation under vacuo. Additional chloroform is added to the syrup and the mixture is poured into excess ammonia dissolved in chloroform and cooled in solid carbon dioxide-acetone. The solid is filtered and extracted with hot absolute alcohol. The solid in the alcohol is precipitated with ether, filtered, and recrystallized from isopropanol. The carbaminoyl-β-methylcholine chloride obtained has a melting point of about 220°C.
Brand nameDuvoid (WellSpring); Myotonachol (Glenwood); Urecholine (Odyssey).
Therapeutic FunctionCholinergic
General DescriptionBethanechol, β-methylcholinechloride carbamate, (2-hydroxypropyl)trimethylammoniumchloride carbamate, carbamylmethylcholinechloride (Urecholine), is nonspecific in its action on muscarinicreceptor subtypes but appears to be more effective ateliciting pharmacological action of M3 receptors. It haspharmacological properties similar to those of methacholine.Both are esters of β-methylcholine and have feeblenicotinic activity. Bethanechol is inactivated more slowlyby AChE in vivo than is methacholine. It is a carbamyl esterand is expected to have stability in aqueous solutions similarto that of carbachol.
HazardHeadache, flushing, gastrointestinal distress, diarrhea, hypotension, excessive salivation, sweating, hypersensitivity.
Mechanism of actionBentanechol is a drug, which has structurally unique qualities of both methacholine and carbachol, i.e. it contains both β-methyl and carbamate functional groups, and quite logically exhibits pharmacological properties of both the drugs. It is resistant to hydrolysis by cholinesterases and has a very minor effect on nicotinic receptors of the autonomic ganglia and neuromuscular junctions. Betanechol has more of a selective action on muscarinic receptors of the gastrointestinal tract and the bladder than do other cholinic esters.
Clinical UseThe main use of bethanechol chloride is in the relief ofurinary retention and abdominal distention after surgery.The drug is used orally and by subcutaneous injection. Itmust never be administered by intramuscular or intravenousinjection because of the danger from cholinergic overstimulationand loss of selective action. Proper administration ofthe drug is associated with low toxicity and no serious sideeffects. Bethanechol chloride should be used with caution inasthmatic patients; when used for glaucoma, it producesfrontal headaches from the constriction of the sphinctermuscle in the eye and from ciliary muscle spasms. Its durationof action is 1 hour.
Chemical SynthesisBetanechol, 2-carbamoyloxy-1-(N,N,N-trimethyl)propyl ammonium chloride (13.1.8), is made by either the subsequent reaction of 1-(N,N,N-trimethylammonium) propan-2-ol with phosgene, followed by ammonia, or by a completely analogous synthesis of carbachol by the reaction of 1-chloro-2-propanol with phosgene followed by consequent reactions with ammonia, and then with trimethylamine, giving betanechol (13.1.8) [14,15].

Veterinary Drugs and TreatmentsIn veterinary medicine, bethanechol is used primarily to stimulate bladder contractions in small animals. It also can be used as an esophageal or general GI stimulant, although metoclopramide and/ or neostigmine have largely supplanted it for these uses.
Bethanechol Preparation Products And Raw materials
Raw materialsAmmonia-->PHOSGENE
Tag:Bethanechol(590-63-6) Related Product Information
BETHANECHOL Sodium chloride Potassium chloride ALUMINUM CLOFIBRATE 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile (2-hydroxypropyl)trimethylammonium Bethanechol Compounds Bethanechol-d6 Chloride Bethanechol-d6 Moclobemide Clofibrate Acetylcholine chloride P-AMINOBENZAMIDE GLUTAMIC ACID Methylene Chloride BETA-METHYLCHOLINE CHLORIDE (2-acetoxyethyl)trimethylammonium L-ACYLASE SUCCINYL CHLORIDE