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Sertraline hydrochloride

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CAS:79559-97-0
Purity:99% Package:3080/KG
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CAS:79559-97-0
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CAS:79559-97-0
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Products Intro: Product Name:Sertraline hydrochloride
CAS:79559-97-0
Purity:99% Package:100g;500g;1kg;25kg...
Sertraline hydrochloride Basic information
Description References
Product Name:Sertraline hydrochloride
Synonyms:(1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE HYDROCHLORIDE;(1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE HYDROCHLORIDE;(1S,4S)-1-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-4-(METHYLAMINO)NAPHTHALENE HYDROCHLORIDE;N-(4(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)NAPHTHALIDENE) METHANAMINE;SERTRALINE HCL FORM I;SERTRALINE HCL FORM II;SERTRALINE HYDROCHLORIDE;SERTRALINE MANDELATE
CAS:79559-97-0
MF:C17H18Cl3N
MW:342.69
EINECS:200-659-6
Product Categories:Pharmaceutical Intermediates;Active Pharmaceutical Ingredients;APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Serotonin receptor;API;KETEK
Mol File:79559-97-0.mol
Sertraline hydrochloride Structure
Sertraline hydrochloride Chemical Properties
Melting point 246-249°C
alpha D23 +37.9° (c = 2 in methanol)
density 1.37
Fp 9℃
storage temp. Desiccate at RT
solubility DMSO: ~26 mg/mL
form solid
pkapKa (water): 9.48 ± 0.04; pKa (methanol:water, 40:60 v/v): 8.6; pKa (ethanol:water, 1:1 v/v): 8.5(at 25℃)
color white
Merck 14,8467
Stability:Store in Freezer
CAS DataBase Reference79559-97-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,T,F
Risk Statements 36/37/38-39/23/24/25-23/24/25-11
Safety Statements 22-24/25-36-26-45-36/37-16-7
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 3
RTECS QJ0352070
HazardClass IRRITANT
MSDS Information
ProviderLanguage
SigmaAldrich English
Sertraline hydrochloride Usage And Synthesis
DescriptionSertraline is the hydrochloride form of sertraliine. Sertraline belongs to the selective serotonin reuptake inhibitor (SSRI) class antidepressant drug. Sertraline is indicated for the treatment of major depressive disorder in adults as well as obsessive-compulsive disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder and social anxiety disorder occurring in both adults and children. Its exact mechanism of action is still not fully understand. But it is indicated that this drug can selectively inhibit the reuptake of serotonin at the presynaptic membrane, increasing serotonin levels in the synapses and enhancing serotonergic neurotransmission. This effect seems to be related to the antidepressant effect of sertraliine.
Referenceshttps://en.wikipedia.org/wiki/Sertraline
https://www.drugbank.ca/drugs/DB01104
Chemical PropertiesWhite Crystalline Powder
UsesA selective serotonin reuptake inhibitor. Used as an antidepressant
Usesantibacterial
UsesA selective ST inhibitor
DefinitionChEBI: A hydrochloride resulting from the reaction of equimolar amounts of sertraline and hydrogen chloride. A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as an antidepressant for the treatment of depression, obsessive-compulsive diso der, panic disorder and post-traumatic stress disorder.
Brand nameZoloft (Pfizer).
Biological ActivityPotent, orally active selective serotonin re-uptake inhibitor (SSRI) used clinically to treat depression.
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