|
|
| | HYDROXY ITRACONAZOLE Basic information |
| Product Name: | HYDROXY ITRACONAZOLE | | Synonyms: | HYDROXY ITRACONAZOLE;3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-;4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one;R 63373;4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)-;Itraconazole 2-Hydroxy Metabolite;Itraconazole metabolite Hydroxy Itraconazole;Itraconazole Impurity 8(Hydroxy Itraconazole) | | CAS: | 112559-91-8 | | MF: | C35H38Cl2N8O5 | | MW: | 721.63 | | EINECS: | | | Product Categories: | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Various Metabolites and Impurities;Isotooe labelled metabolites;metabolites;Isotopically Labeled Pharmaceutical Reference Standard | | Mol File: | 112559-91-8.mol |  |
| | HYDROXY ITRACONAZOLE Chemical Properties |
| Melting point | 76-78°C | | Boiling point | 884.7±75.0 °C(Predicted) | | density | 1.44±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | form | Solid | | pka | 14.72±0.20(Predicted) | | color | White to Pale Beige |
| | HYDROXY ITRACONAZOLE Usage And Synthesis |
| Description | Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole . Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively). Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections. | | Chemical Properties | Off-White Crystalline Solid | | Uses | A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product. |
| | HYDROXY ITRACONAZOLE Preparation Products And Raw materials |
|