|
| 5-METHOXY-2-METHYLINDOLE Basic information |
| 5-METHOXY-2-METHYLINDOLE Chemical Properties |
Melting point | 86-88 °C (lit.) | Boiling point | 145 °C / 1.5mmHg | density | 1.0840 (rough estimate) | refractive index | 1.5200 (estimate) | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | solubility | Soluble in methanol (very faint turbidity.) | pka | 17.28±0.30(Predicted) | form | Crystalline Powder or Crystals | color | White to light beige | InChIKey | VSWGLJOQFUMFOQ-UHFFFAOYSA-N | CAS DataBase Reference | 1076-74-0(CAS DataBase Reference) |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 37/39-26 | WGK Germany | 3 | HazardClass | IRRITANT | HS Code | 29339900 |
| 5-METHOXY-2-METHYLINDOLE Usage And Synthesis |
Description | 5-methoxy-2-methylindole is a useful organic raw material. It can be used as the reactant in the preparation of indolylquinoxalines by condensation reactions, in preparation of alkylindoles via Ir-catalyzed reductive alkylation, in arylation reactions in the presence of a palladium acetate catalyst, in enantioselective Friedel-Crafts alkylation, as well as in stereo selective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. It is also employed in inhibiting the chlorinating activity of myeloperoxidase (MPO) and in the metabolic synthesis of acrylacetic acid anti-inflammatory synthesis. | Chemical Properties | white to light beige crystalline powder or | Uses | It is employed as a reactant in preparation of indolylquinoxalines by condensation reactions, reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation, reactant in arylation reactions using a palladium acetate catalyst, reactant in enantioselective Friedel-Crafts alkylation and reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. As an indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid anti-inflammatory synthesis. | Uses | reactant in preparation of indolylquinoxalines by condensation reactions1reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation2reactant in arylation reactions using a palladium acetate catalyst3reactant in enantioselective Friedel-Crafts alkylation4reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation5 | Uses | An indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid antiinflammatory synthesis. | Definition | ChEBI: 5-Methoxy-2-methyl-1H-indole is a member of indoles. | References | https://www.alfa.com/en/catalog/B21348/
http://www.sigmaaldrich.com/catalog/product/aldrich/m15451?lang=en®ion=US
https://pubchem.ncbi.nlm.nih.gov/compound/5-Methoxy-2-methylindole#section=2D-Structure |
| 5-METHOXY-2-METHYLINDOLE Preparation Products And Raw materials |
|