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| | METHYL-(3-HYDROXYPROPYL) SULFONE Basic information |
| Product Name: | METHYL-(3-HYDROXYPROPYL) SULFONE | | Synonyms: | 3-(methylsulfonyl)-1-propano;3-hydroxypropylmethylsulfone;METHYL-(3-HYDROXYPROPYL) SULFONE;3-(methylsulfonyl)-1-propanol(SALTDATA: FREE);3-(Methylsulfonyl)propan-1-ol;3-(Methanesulfonyl)-1-propanol;Ba 2769;3-(Methylsulfonyl)-1-propanol | | CAS: | 2058-49-3 | | MF: | C4H10O3S | | MW: | 138.19 | | EINECS: | | | Product Categories: | | | Mol File: | 2058-49-3.mol |  |
| | METHYL-(3-HYDROXYPROPYL) SULFONE Chemical Properties |
| Boiling point | 349.4±25.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 14.57±0.10(Predicted) | | form | solid | | color | White to off-white |
| Hazard Codes | T | | Risk Statements | 25-36 | | Safety Statements | 26-45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | HazardClass | IRRITANT | | PackingGroup | Ⅲ | | HS Code | 2905599890 | | Toxicity | mouse,LD50,intravenous,> 5gm/kg (5000mg/kg),Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 242, 1971. |
| | METHYL-(3-HYDROXYPROPYL) SULFONE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-methylsulfonyl-1-propanol from 3-methylthiopropanol: 3-methylthiopropanol (200 g, 1900 mmol) was dissolved in dichloromethane (2000 ml). The reaction mixture was cooled to 0°C. An 85% aqueous solution of m-chloroperoxybenzoic acid (970 g, 5700 mmol) was added in batches while maintaining the temperature between 0 and 5 °C. After the addition was completed, the reaction mixture was slowly warmed to 25 °C and the reaction was stirred at this temperature for 15 hours. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad. The filtrate was purified by fast column chromatography (eluent: petroleum ether/ethyl acetate = 3:1, followed by ethyl acetate/methanol = 10:1) to afford the target product 3-methylsulfonyl-1-propanol (75 g, 29% yield). | | References | [1] Patent: WO2012/80447, 2012, A1. Location in patent: Page/Page column 18
[2] Patent: WO2012/80450, 2012, A1. Location in patent: Page/Page column 27
[3] Patent: WO2012/80449, 2012, A1. Location in patent: Page/Page column 20
[4] Patent: US2013/267555, 2013, A1. Location in patent: Paragraph 0092-0094
[5] Patent: WO2013/186335, 2013, A1. Location in patent: Page/Page column 78; 79 |
| | METHYL-(3-HYDROXYPROPYL) SULFONE Preparation Products And Raw materials |
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