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Fludarabine

Fludarabine Suppliers list
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Fludarabine
CAS:21679-14-1
Purity:99% Package:88000/KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Fludarabine
CAS:21679-14-1
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Fludarabine
CAS:21679-14-1
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:21679-14-1
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Fludarabine
CAS:21679-14-1

Lastest Price from Fludarabine manufacturers

  • Fludarabine
  • US $1.00 / KG
  • 2019-05-13
  • CAS:21679-14-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000KG
  • Fludarbine
  • US $10.00 / KG
  • 2019-01-15
  • CAS:21679-14-1
  • Min. Order: 10G
  • Purity: 99%
  • Supply Ability: 10MT
Fludarabine Basic information
Product Name:Fludarabine
Synonyms:2-Fluoroadeninearabinoside;9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin;9-beta-d-arabinofuranosyl-2-fluoro-adenin;f-ara-a;6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE;9--D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine;NSC 118218;NSC 118218H
CAS:21679-14-1
MF:C10H12FN5O4
MW:285.23
EINECS:244-525-5
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;API;F-ara-A, NSC 118218;Anti-cancer&immunity;Inhibitors;-
Mol File:21679-14-1.mol
Fludarabine Structure
Fludarabine Chemical Properties
Melting point 265-268°C
alpha D25 +17 ±2.5° (c = 0.1 in ethanol)
storage temp. 2-8°C
solubility DMF: 20 mg/mL, clear, faintly yellow
form Powder
color White to Pale Yellow
Water Solubility Soluble in DMF, DMSO, methanol or ethanol. Sparingly soluble in water
Merck 13,4152
BRN 1225932
CAS DataBase Reference21679-14-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 23/24/25-36/37/38-39/23/24/25-39-22
Safety Statements 26-36/37-45-36
WGK Germany 3
RTECS AU6207000
10
Hazardous Substances Data21679-14-1(Hazardous Substances Data)
MSDS Information
ProviderLanguage
9-bata-D-Arabinofuranosyl-2-fluoroadenine English
SigmaAldrich English
Fludarabine Usage And Synthesis
Chemical PropertiesWhite Solid
UsesUsed as an antineoplastic
UsesA STAT-1 activation inhibitor and a DNA synthesis inhibitor.?
Usesphosphate as antineoplastic;inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase
UsesIrreversible muscarinic agonist
UsesDNA synthesis and methylation inhibitor;A cell permeable agent that interferes with DNA synthesis and repair; also inhibits RNA transcription
General DescriptionThe drug is available as the phosphate salt in a 50-mg vialfor IV use. Fludarabine is used to treat chronic lymphocyticleukemia and non-Hodgkin’s lymphoma. The mechanism ofaction involves the triphosphate metabolite and its inhibitionof DNA chain elongation. The 2-fluoro group on the adeninering renders fludarabine resistant to breakdown byadenosine deaminase. The drug is rapidly dephosphorylatedto 2-fluoro-ara-adenosine (F-ara-A) after administration. Fara-A is taken into the cell and subsequently re-phosphorylatedto yield the triphosphate (F-ara-ATP), the active drugspecies. Resistance can occur via decreased expression ofthe activating enzymes and decreased drug transport.Fludarabine is orally bioavailable and is distributed throughoutthe body reaching high levels in liver, kidney, andspleen. The drug is metabolized to F-ara-A, which enterscells via the nucleoside transport system and is rephosphorylatedby deoxycytidine kinase to fludarabine monophosphateand finally fludarabine triphosphate, the activespecies. About 25% of F-ara-A is excreted unchanged inurine. Drug interactions include an increased incidence offatal pulmonary toxicity when fludarabine is used in combinationwith pentostatin. Additionally, fludarabine may potentiate the effects of several other anticancer drugs includingcytarabine, cyclophosphamide, and cisplatin.Toxicities include myelosuppression, immunosuppression,fever, nausea, and vomiting.
Biological ActivityPurine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Displays anticancer activity against hematological malignancies in vivo .
Fludarabine Preparation Products And Raw materials
Raw materialsAcetic anhydride-->Fluoroboric acid-->Boron trichloride -->2,4,5,6-TETRAAMINOPYRIMIDINE-->2,6-Diaminopurine-->DIACETAMIDE
Tag:Fludarabine(21679-14-1) Related Product Information
Temozolomide Gemcitabine hydrochloride Fludarabine Phosphate α-Chloropropionyl Chloride Flufenacet 6-AMINO-2-FLUORO-9-(2,3,5-TRI-O-BENZYL-BETA-D-ARABINOFURANOSYL)-9H-PURINE 2-FLUORO-6-(1,2,4-TRIAZOL-1-YL)-9-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-9H-PURINE 2-Fluoro-9-β-D-(2',3',5'-tri-O- acetyl arabinofuranosyl)-adenine 6-BENZYLOXYAMINO-9-(5-O-DIPHENYLPHOSPHONO-BETA-D-ARABINOFURANOSYL)-2-FLUORO-9H-PURINE 2-FLUOROADENINE-BETA-D-ARABINOFURANOSIDE, [8-3H]- FLUDARABINE PHOSPHATE (FLUDARABINE 5''-MONOPHOSPHATE),fludarabine hcl,FLUDARABINE PHOSPHATE 2-FLUORO-6-(1,2,4-TRIAZOL-1-YL)-9-(BETA-D-ARABINOFURANOSYL)-9H-PURINE 2-FLUOROADENINE-BETA-D-ARABINOFURANOSIDE 5'-MONOPHOSPHATE, DIAMMONIUM SALT, [8-3H]- Flutamide Danazol Tadalafil Triflusulfuron-methyl FLUMIOXAZIN Flumetralin