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TREHALOSE

TREHALOSE Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:TREHALOSE
CAS:99-20-7
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:99-20-7
CAS:99-20-7
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366 E-mail:sales03@shyrchem.com
Email: sales03@shyrchem.com
Products Intro: Product Name:D-(+)-Trehalose Anhydrous
CAS:99-20-7
Purity:99% Package:100g;500g;1kg;25kg...
Company Name: Hebei Chishuo Biotechnology Co., Ltd.
Tel: +86 311 66567340
Email: luna@speedgainpharma.com
Products Intro: Product Name:D-Trehalose anhydrous
CAS:99-20-7
Purity:99 Package:1KG;100USD
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Trehalose
CAS:99-20-7
Purity:HPLC>=98% Package:20mg

Lastest Price from TREHALOSE manufacturers

  • Trehalose
  • US $0.00 / mg
  • 2020-05-11
  • CAS:99-20-7
  • Min. Order: 20mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 10 g
  • TREHALOSE
  • US $50.00 / KG
  • 2019-07-06
  • CAS:99-20-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000kg
TREHALOSE Basic information
Description References
Product Name:TREHALOSE
Synonyms:D-(+)-TREHALOSE;D-TREHALOSE;(2R,2'R,3S,3'S,4S,4'S,5R,5'R,6R,6'R)-6,6'-oxybis(2-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol);TREHALOSE(P);ALPHA-D-TREHALOSE;ALPHA,ALPHA-D-TREHALOSE;MYCOSE;TREHALOSE
CAS:99-20-7
MF:C12H22O11
MW:342.3
EINECS:202-739-6
Product Categories:Basic Sugars (Mono & Oligosaccharides);Biochemistry;Disaccharides;Sugars;Natural Plant Extract;Sweeteners
Mol File:99-20-7.mol
TREHALOSE Structure
TREHALOSE Chemical Properties
Melting point 203 °C
Boiling point 397.76°C (rough estimate)
density 1.5800
refractive index 197 ° (C=7, H2O)
RTECS LZ5776770
solubility Soluble in water; very slightly soluble in ethanol (95%); practically insoluble in ether.
pka12.53±0.70(Predicted)
form Powder
color White to Off-white
Water Solubility Soluble in water.
Sensitive Hygroscopic
Merck 14,9580
CAS DataBase Reference99-20-7(CAS DataBase Reference)
EPA Substance Registry SystemTrehalose (99-20-7)
Safety Information
Hazard Codes Xi
Risk Statements 38
Safety Statements 37/39-26
TSCA Yes
HS Code 29400090
MSDS Information
ProviderLanguage
ACROS English
TREHALOSE Usage And Synthesis
DescriptionTrehalose is a nonreducing disaccharide in which the two glucose molecules are linked together in an α,α-1,1-glycosidic linkage. α,α-trehalose is the only anomer of trehalose, which has been isolated from and biosynthesized in living organisms. This sugar is present in a wide variety of organisms, including bacteria, yeast, fungi, insects, invertebrates, and lower and higher plants, where it may serve as a source of energy and carbon.  It can be used as a stabilizer and protectant of proteins and membranes: protection from dehydration; protection from damage by oxygen radicals (against oxidation); protection from cold; as a sensing compound and/or growth regulator; as a structural component of the bacterial cell wall. Trehalose is used in the biopharmaceutical preservation of labile protein drugs and in the cryopreservation of human cells. It is used as an ingredient for dried and processed food, and as an artificial sweetener, with a relative sweetness of 40-45% that of sucrose. Several safety studies on trehalose have been evaluated by JECFA, 2001 and allocated an ADI of ‘not specified’. Trehalose is approved in Japan, Korea, Taiwan, and UK. Trehalose could be possibly used in an eye drop solution to against corneal damage due to desiccation (dry eye syndrome).
References[1] Alan D. Elbein, Y.T. Pan, Irena Pastuszak, David Carroll (2003): New insights on trehalose: a multifunctional molecule, 13, 17R-27R.
[2] A.B Richards, S Krakowka, L.B Dexter, H Schmid, A.P.M Wolterbeek, D.H Waalkens-Berendsen, A Shigoyuki, M Kurimoto (2002): Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies, 40, 871-898.
[3] Alex Patist, Hans Zoerb (2005): Preservation mechnisams of trehalose in food and Biosystems, 40, 107-113.
[4] Sanchari Chattopadhyay, Utpal Raychaudhuri, Runu Chakraborty (2014): Artificial sweeteners – a review, 51, 611-621.
[5] http://www.life-enhancement.com/magazine/article/2453-trehalose-for-dry-eyes
Chemical Propertieswhite to off-white crystalline powder
Chemical PropertiesTrehalose occurs as virtually odorless, white or almost white crystals with a sweet taste (approximately 45% of the sweetness of sucrose).
Usestrehalose is a humectant and moisturizer, it helps bind water in the skin and increase the skin’s moisture content. It is a naturally occurring plant sugar.
Production MethodsTrehalose is prepared from liquefied starch by a multistep enzymatic process. The commercial product is the dihydrate.
DefinitionChEBI: A trehalose in which both glucose residues have alpha-configuration at the anomeric carbon.
Pharmaceutical ApplicationsTrehalose is used for the lyoprotection of therapeutic proteins, particularly for parenteral administration. Other pharmaceutically relevant applications include use as an excipient for diagnostic assay tablets; for stabilization during the freeze–thaw and lyophilization of liposomes; and for stabilization of blood cells, cosmetics, and monoclonal antibodies. Trehalose may also be used in formulations for topical application.
SafetyTrehalose is used in cosmetics, foods, and parenteral and nonparenteral pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.
In the gut, trehalose is rapidly metabolized to glucose by the specific enzyme trehalase. A small minority of the population exhibits a primary (hereditary) or secondary (acquired) trehalase deficiency and thus may experience intestinal discomfort after ingestion of excessive amounts of trehalose owing to the osmotic activity of undigested trehalose in the gut. However, smaller amounts of trehalose are tolerated by such individuals without any symptoms.
Trehalose is used as a sweetener and is reported to have substantially less cariogenic potential than sucrose.
LD50 (dog, IV): >1 g/kg
LD50 (dog, oral): >5 g/kg
LD50 (mouse, IV): >1 g/kg
LD50 (mouse, oral): >5 g/kg
LD50 (rat, IV): >1 g/kg
LD50 (rat, oral): >5 g/kg
storageTrehalose is a relatively stable material. At 60°C for 5 hours it loses not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high relative humidity (≥90%).
Trehalose should be stored in a cool, dry place in a well-sealed container.
IncompatibilitiesTrehalose is incompatible with strong oxidizing agents, especially in the presence of heat.
Regulatory StatusGRAS listed. In the UK trehalose may be used in certain food applications. Included in parenteral and nonparenteral investigational formulations.
TREHALOSE Preparation Products And Raw materials
Tag:TREHALOSE(99-20-7) Related Product Information
ALPHA,SS-TREHALOSE OCTAACETATE trehalose-6-phosphate synthase-phosphatase complex 4-azido-4-deoxy-alpha,alpha-trehalose Trehalose 6-phosphate alpha,alpha-trehalose phosphorylase alpha,alpha-trehalose-phosphate synthase(GDP-forming) α,α-trehalose glucohydrolase 3-deoxymaltosyl-1-4-alpha,alpha-trehalose trehalose 6,6'-dipalmitate maltooligosyl trehalose trehalohydrolase trehalose-phosphatase trehalose 6,6'-dimycolate from mycobacterium tuberculosis,6,6'-di-o-mycoloyl-α,α-trehalose,TREHALOSE 6,6'-DIMYCOLATE FROM*MYCOBACTE RIUM TUBERC TREHALOSE, ALPHA-D-, [14C(U)] 6,6'-dibehenoyl-α,α'-trehalose TREHALOSE TREHALOSE OCTAACETATE α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside,α,α-Trehalose, D-(+)-Trehalose dihydrate, α-D-Glucopyranosyl-α-D-glucopyranoside,D-(+)-TREHALOSE DIHYDATE,D-TREHALOSE DIHYDRATE extrapure CHR,d(+)-trehalose dihydrate, mycose,D-(+)-TREHALOSE,DIHYDRATE,POTATO,D-(+)-TREHALOSE DIHYDRATE FROM*SACCHAROM YCES CEREVI,D(+)TREHALOSE REDUCED METAL ION CONTENT DIHYDRATE,D(+)TREHALOSE DIHYDRATE CELL*CULTURE TES TED,D(+)-TREHALOSE DIHYDRATE, FOR MICRO-BIOL OGY Actinotetraose Hexatiglate