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| | N-Succinimidyl 6-maleimidohexanoate Basic information |
| | N-Succinimidyl 6-maleimidohexanoate Chemical Properties |
| Melting point | 70-73 °C(lit.) | | Boiling point | 480.6±47.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | chloroform: 100mg/mL | | form | powder | | pka | -2.21±0.20(Predicted) | | color | Off-white to pale brown | | Sensitive | Light & Moisture Sensitive & Hygroscopic | | BRN | 1499815 | | InChI | InChI=1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2 | | InChIKey | VLARLSIGSPVYHX-UHFFFAOYSA-N | | SMILES | N1(CCCCCC(ON2C(=O)CCC2=O)=O)C(=O)C=CC1=O | | CAS DataBase Reference | 55750-63-5(CAS DataBase Reference) |
| | N-Succinimidyl 6-maleimidohexanoate Usage And Synthesis |
| Description | Mal-heptanoic NHS ester contains a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | | Chemical Properties | White to cream colored crystals | | Uses | 6-Maleimidohexanoic acid N-hydroxysuccinimide ester can be used in:
- Synthesis of maleimide-activated carbohydrates for site-specific glycosylation of cysteine-containing peptides and proteins via maleimide-thiol ligation reaction.
- Synthesis of a glucuronide prodrug of doxorubicin bearing a maleimide side chain as an antitumor agent.
- Cross-linking oligonucleotides with the amino groups on the substrate to fabricate DNA microarrays.
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| | N-Succinimidyl 6-maleimidohexanoate Preparation Products And Raw materials |
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