Company Name: |
BOC Sciences
|
Tel: |
1-631-485-4226; 16314854226 |
Email: |
info@bocsci.com |
Products Intro: |
Product Name:(R)-Bromoenol lactone CAS:478288-90-3 Purity:98% Remarks:(R)-Bromoenol lactone is an irreversible inhibitor of iPLA2γ.
|
Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
Tel: |
400-9205774 |
Email: |
sales@glpbio.cn |
Products Intro: |
Product Name:(R)-Bromoenol lactone CAS:478288-90-3 Purity:>98% Package:1mg;10mg;50mg;100mg;
|
Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
Tel: |
18818260767 |
Email: |
sales@chemegen.com |
Products Intro: |
Product Name:(R)-Bromoenol lactone CAS:478288-90-3 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
Company Name: |
MedBioPharmaceutical Technology Inc
|
Tel: |
021-69568360 18916172912 |
Email: |
order@med-bio.cn |
Products Intro: |
Product Name:(R)-BEL CAS:478288-90-3 Purity:98% Package:5mg (solution); 10mg (solution); 500ug (solution); 1mg (solution) Remarks:Medbio
|
Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
Tel: |
021-65675885 18964387627 |
Email: |
customer_service@efebio.com |
Products Intro: |
Product Name:(R)-Bromoenol lactone CAS:478288-90-3 Purity:98% Package:500μg;1mg;5mg
|
|
| (R)-BEL Basic information |
Product Name: | (R)-BEL | Synonyms: | (R)-BEL;(R)-BROMOENOL LACTONE;6E-(BROMOMETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE;(3R,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one;(R) Bromoenol lactone,(R)Bromoenol lactone;2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3R,6E)- | CAS: | 478288-90-3 | MF: | C16H13BrO2 | MW: | 317.18 | EINECS: | | Product Categories: | | Mol File: | 478288-90-3.mol | |
| (R)-BEL Chemical Properties |
Boiling point | 467.0±45.0 °C(Predicted) | density | 1.538±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): .05 mg/ml |
| (R)-BEL Usage And Synthesis |
Description | The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.1 The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 μM.2 (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM. | References | 1. Balsinde, J., Balboa, M.A., Insel, P.A., et al. Regulation and inhibition of phospholipase A2 Annu. Rev. Pharmacol. Toxicol. 39,175-189(1999). 2. Jenkins, C.M., Han, X., Mancuso, D.J., et al. Identification of calcium-independent phospholipase A2 (iPLA2)β, and not iPLA2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells J. Biol. Chem. 277(36),32807-32814(2002). |
| (R)-BEL Preparation Products And Raw materials |
|