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Bufalin

Bufalin Suppliers list
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: 18080483897
Email: maggie@biopurify.com
Products Intro: Product Name:Bufalin
CAS:465-21-4
Purity:98% HPLC Package:20mg;100mg;500mg;1g Remarks:BP0288
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Bufalin
CAS:465-21-4
Purity:HPLC>=98% Package:20mg
Company Name: Baoji Herbest Bio-Tech Co.,Ltd.  Gold
Tel: +86-917-8888998
Email: herbest3@gmail.com
Products Intro: Product Name:Bufalin
CAS:465-21-4
Purity:98% HPLC Package:20Mg;1g
Company Name: Shanghai BeiZhuo Biotech Co., Ltd.  Gold
Tel: 021-61119791/13386096464
Email: bzswkf@foxmail.com
Products Intro: Product Name:Bufalin
CAS:465-21-4
Purity:HPLC>=98%
Company Name: Chengdu Biopurify Phytochemicals Ltd.  Gold
Tel: 86-28-82633397
Email: sales@biopurify.com
Products Intro: Product Name:Bufalin
CAS:465-21-4
Purity:>95%,98%,99% by HPLC-UV or HPLC-ELSD Package:From mgs to grams, According to customer request. Inquire for Bulk scale.
Bufalin Basic information
Pharmacological effects Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Product Name:Bufalin
Synonyms:22-dienolide,3,14-dihydroxy-,(3-beta,5-beta)-bufa-2;Bufalin, >=98%;Bufalin, 98%, from bufonis venenum;22-dienolide,3-beta,14-dihydroxy-5-beta-bufa-2;BUFA-20,22-DIENOLIDE, 3,14-DIHYDROXY-, (3B,5B)-;BUFALIN;(3BETA,5BETA)-3,14-DIHYDROXYBUFA-20,22-DIENOLIDE;3-BETA-14-DIHYDROXY-5-BETA-BUFA-20,22-DIENOLIDE
CAS:465-21-4
MF:C24H34O4
MW:386.52
EINECS:
Product Categories:reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;chemical reagent;pharmaceutical intermediate;phytochemical
Mol File:465-21-4.mol
Bufalin Structure
Bufalin Chemical Properties
Melting point 242-243°
alpha D -20°
storage temp. 2-8°C
Safety Information
Hazard Codes T+
Risk Statements 28
Safety Statements 28-36/37-45
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS EI2962500
HazardClass 6.1(a)
PackingGroup II
MSDS Information
Bufalin Usage And Synthesis
Pharmacological effectsBufalin is one of the main components of dried secretions of toad which is Bufo , Bufalin has a strong surface anesthetic effect, and it has a long-lasting effect in rabbit cornea and human tongue tests which is stronger than cocaine, about 90 times of cocaine. intravenous fluid Toad (0.05mg/kg) on Anesthetized rabbits , anesthetized rabbits can be caused breathing excitement, cat can also be caused breathe excitement . Its effect is stronger than nikethamide , pentylenetetrazol, lobeline, etc. and it can antagonize morphine respiratory depression. Respiratory stimulant order: Bufalin>Resibufogenin= Cinobufagin =cinobufotaline> Japanese toad toxins.
Bufalin low concentrations (10-4) promote release of presynaptic acetylcholine on rat diaphragm , while high concentrations promote first then inhibit, and partly antagonize the neuromuscular blocking effects of Mg2 +,but no inhibition on choline esterase.
The above information is edited by the Chemicalbook of Tian Ye.
CategoryToxic substances
Toxicity gradingHighly toxic
Acute toxicityIntraperitoneal-mouse LD50: 2.2 mg/kg
Flammability and hazard characteristicsFlammable,the fire produces acrid smoke .
Storage CharacteristicsVentilated, low-temperature ,dry storeroom,separate from food raw materials .
Extinguishing agentWater, carbon dioxide, dry powder,sandy soil
UsesA bufadienolide derivative, cardiac steroid, a component of bufadienolides present in the traditional Chinese medicine Chan'su, used therapeutically for the treatment of heart disease, also has been reported as a protective factor in many tumors.
DefinitionChEBI: A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo.
HazardToxic.
Bufalin Preparation Products And Raw materials
Tag:Bufalin(465-21-4) Related Product Information
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