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| | 2,3-dimethyl-6-nitro-2H-indazole Basic information |
| Product Name: | 2,3-dimethyl-6-nitro-2H-indazole | | Synonyms: | 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE;2,3-dimethyl-6-nitro-1H-indazole;2,3-Dimethyl-6-nitro-1H-i...;2H-Indazole, 2,3-diMethyl-6-nitro-;3-Methly-6-nitroindazole;3-diMethyl-6-nitro-2H-indazole;Pazopanib Impurity 19;2,3-dimethyl-6-nitro-indazole | | CAS: | 444731-73-1 | | MF: | C9H9N3O2 | | MW: | 191.19 | | EINECS: | 610-189-7 | | Product Categories: | | | Mol File: | 444731-73-1.mol |  |
| | 2,3-dimethyl-6-nitro-2H-indazole Chemical Properties |
| Melting point | 183-186°C | | Boiling point | 377.0±22.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | -0.55±0.30(Predicted) | | form | Solid | | color | Yellow |
| | 2,3-dimethyl-6-nitro-2H-indazole Usage And Synthesis |
| Uses | 2,3-Dimethyl-6-nitro-2H-indazole is an impurity in the synthesis of Pazopanib (P210925) hydrochloride, an oral angiogenesis inhibitor targeting VEGFR and PDGFR. | | structure and hydrogen bonding |
In the mol-ecule of 2,3-dimethyl-6-nitro-2H-indazole, C9H9N3O2, the indazole ring system is almost planar [maximum deviation = 0.019 (3) Å for the C atom bearing the nitro group]. In the crystal structure, inter-molecular C—H...O inter-actions link the mol-ecules into centrosymmetric dimers, forming R 2 2(18) ring motifs. Aromatic π–π contacts between indazole rings [centroid–centroid distances = 3.632 (1) and 3.705 (1)?] may further stabilize the structure[1].
| | References | [1] Yan Chen, Ping Wei, Zheng Fang. “2,3-Dimethyl-6-nitro-2H-indazole.” Acta crystallographica. Section E, Structure reports online 65 Pt 8 (2009): o1775.
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| | 2,3-dimethyl-6-nitro-2H-indazole Preparation Products And Raw materials |
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