ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Endocrinology & Hormones >Androgen Receptor agonists >Andarine

Andarine

Andarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, and it is tissue selective for the metabolic organ. Phase 3.
Andarine Suppliers list
Company Name: Hebei Henghe Import and Export Trading Co. LTD
Tel: 18032916000
Email: rose@hbtycoon.com
Products Intro: Product Name:Sarms mk 2866
CAS:401900-40-1
Purity:99% Package:1g;2USD
Company Name: Hebei Jimi Trading Co., Ltd.
Tel: +86 319 5273535
Email: bestoneforyou@sina.com
Products Intro: Product Name:MK2866
Purity:99.8% Package:1KG;1400USD
Company Name: Cangzhou Wanyou New Material Technology Co.,Ltd
Tel: 18631714998
Email: sales@czwytech.com
Products Intro: Product Name:Andarine (S-4) S4 Gtx-007
CAS:401900-40-1
Purity:99% Package:1g;1USD
Company Name: Shanghai Longyu Biotechnology Co., Ltd.
Tel:
Email: info@longyupharma.com
Products Intro: Product Name:AndarineS-4;Andarine;S4;MK-2866;MK2866
CAS:401900-40-1
Purity:98% plus Package:1ASSAYS;1USD Remarks:Accept Paypal/western union/bitcoin/money gram/alibaba trade assurance
Company Name: WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Tel: 027-81302090
Email: 2851686515@qq.com
Products Intro: Product Name:MK-2866
CAS:401900-40-1
Purity:99% Package:1KG;USD

Lastest Price from Andarine manufacturers

  • S4/Andarine
  • US $0.00 / KG
  • 2021-02-25
  • CAS:401900-40-1
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • MK2866
  • US $0.00 / KG
  • 2021-02-25
  • CAS:
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • SR9009 Stenabolic
  • US $1.00 / BOU/Drum
  • 2020-11-24
  • CAS:401900-40-1
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1kg

Related articles

  • What is Andarine?
  • The pharmacological activity of andarine, as an effective anabolic agonist without side-effects, has been studied in vitro and....
  • Feb 19,2020
Andarine Basic information
Selective Androgen Receptor Modulator Clinical Application Biological activity In vitro In vivo Characteristics
Product Name:Andarine
Synonyms:S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide;N-[4-Nitro-3-(trifluoromethyl)phenyl]-(2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methylpropanamide;Ostarine;S4 Powder Andarine GTX-007 SARM Steroids CAS 401900-40-1 for Muscle Building,mk-2866,MK-2866;CS-418;Andarine(S4) whnohe_caroline(at)163.com;Andarine(S4),whnohe_lucy(at)163.com;(1132656-73-5) ostarine
CAS:401900-40-1
MF:C19H18F3N3O6
MW:441.36
EINECS:803-892-7
Product Categories:Inhibitors;SARMS;Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;APIs;Pharmaceuticals
Mol File:401900-40-1.mol
Andarine Structure
Andarine Chemical Properties
Melting point 70-74℃
Boiling point 698.7±55.0 °C(Predicted)
density 1.47
storage temp. Refrigerator
pka12.13±0.29(Predicted)
form neat
BRN 9666695
InChIKeyYVXVTLGIDOACBJ-SFHVURJKSA-N
Safety Information
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
WGK Germany 3
MSDS Information
Andarine Usage And Synthesis
Selective Androgen Receptor Modulator

Andarine (MK-2866), as the arylpropionamide derivate, has been developed in pharmaceutical industry as a new class of therapeutics called Selective Androgen Receptor Modulator (SARM, either agonists or antagonists at particular androgen receptors) with specific selectivity for particular tissues and organs, that could substitute the synthetic anabolic drugs used in medical treatments.

Clinical Application

The pharmacological activity of andarine suggest the great potential of andarine in the development of the clinically available SARMs, which offers unique therapeutic advantages over their steroidal counterparts and an exciting opportunity to differentially regulate the androgen effects in various target tissues, thus minimizing the interference to normal. Thus, andarine has promising in advanced clinical trials that aim to treat age-related maladies and to counteract symptoms of severe diseases such as sarcopenia and cancer cachexia.
However, andarine may be misused in sports where athletes and/or their handlers may seek to gain unfair advantage. Therefore, andarine as agonist is prohibited for use by the International Federation of Horseracing Authorities and the World Anti-Doping Agency.

Biological activityAndarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, and it is tissue selective for the metabolic organ. Phase 3.
In vitroIn vitro, Andarine binds to androgen receptors with high affinity with Ki of 4 nM. Moreover, 10 nM Andarine stimulated the transcription adjusted by androgen receptor, up to 93%.
In vivoIn vivo, Andarine has an effective metabolic activity, and stimulates the growth of the prostate, seminal vesicle, and levator ani, with ED50 is 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day respectively. This effect is dose dependent. In addition, Andarine acts on FSH, which does not affect some physiological changes caused by castration, and at a dose of 0.5 mg or more per day, partially inhibiting LH production. Andarine was administered to dog intravenously at 0.1, 1, 3, and 10 mg/kg doses, then the total body clearance (CL) decreased from 7.4 mL/min/kg to 3.1 mL/min/kg, the steady-state volume (Vss) was 1.39 L/kg and the half-life was 229 minutes. In addition, Andarine was 10 mg/kg, 1 mg/kg and 0.1 mg/kg, with oral bioavailability of 38%, 62% and 91% respectively. Andarine has tissue selective pharmacological activity and is well treated with 0.5 mg/day concentration, significantly reducing prostate weight to 79.4%.
CharacteristicsAndarine is a selective non-steroidal androgen receptor (AR) agonist.
Chemical PropertiesPale Yellow Solid
UsesIt is a potent and tissue-selective androgen receptor modulator (SARM)
Andarine Preparation Products And Raw materials
Tag:Andarine(401900-40-1) Related Product Information
Defactinib Saracatinib CRA-02478 (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide BMS-754807 Doxorubicin hydrochloride